TGL5 triacylglycerol lipase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TGL5
Official Full Name: triacylglycerol lipase
Primary source: SGD:S000005607
Locus tag: YOR081C
See related: AllianceGenome:SGD:S000005607; FungiDB:YOR081C; VEuPathDB:YOR081C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: STC2
Summary: Enables lysophosphatidic acid acyltransferase activity and triacylglycerol lipase activity. Involved in triglyceride mobilization. Located in lipid droplet. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TGL5 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (476939..479188, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results demonstrate that yeast Tgl3p and Tgl5p play a dual role in lipid metabolism contributing to both anabolic and catabolic processes.
Title: Janus-faced enzymes yeast Tgl3p and Tgl5p catalyze lipase and acyltransferase reactions.
The identification of Tgl4p and Tgl5p as additional TAG lipases of the yeast is reported.
Title: Tgl4p and Tgl5p, two triacylglycerol lipases of the yeast Saccharomyces cerevisiae are localized to lipid particles.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lysophosphatidic acid acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables triacylglycerol lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables triacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info
enables triacylglycerol lipase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sporulation resulting in formation of a cellular spore	IEA Inferred from Electronic Annotation more info
involved_in triglyceride metabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride mobilization	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride mobilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in lipid droplet	HDA more info	PubMed
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: triacylglycerol lipase

NP_014724.1

EC 3.1.1.3

Bifunctional triacylglycerol lipase and LPA acyltransferase; lipid particle-localized triacylglycerol (TAG) lipase involved in triacylglycerol mobilization; catalyzes acylation of lysophosphatidic acid (LPA); potential Cdc28p substrate; TGL5 has a paralog, TGL4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

476939..479188 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183500.1 → NP_014724.1 TPA: triacylglycerol lipase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014724.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2E4, Q12043, Q7LH13

UniProtKB/TrEMBL

A6ZNT3, B3LJD0, C7GT34, C8ZI43, G2WMV9, N1NWI8

Conserved Domains (2) summary

cd07230
Location:110 → 537

Pat_TGL4-5_like; Triacylglycerol lipase 4 and 5

pfam11815
Location:40 → 176

DUF3336; Domain of unknown function (DUF3336)