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ATX2 Mn(2+) transporter ATX2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854246, updated on 2-Nov-2024

Summary

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Official Symbol
ATX2
Official Full Name
Mn(2+) transporter ATX2
Primary source
SGD:S000005605
Locus tag
YOR079C
See related
AllianceGenome:SGD:S000005605; FungiDB:YOR079C; VEuPathDB:YOR079C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YOR29-30
Summary
Enables manganese ion transmembrane transporter activity. Involved in intracellular manganese ion homeostasis. Located in Golgi membrane; late endosome; and trans-Golgi network. Orthologous to human SLC39A9 (solute carrier family 39 member 9). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ATX2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (473475..474416, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rts2p Neighboring gene Bud21p Neighboring gene DNA-binding SCF ubiquitin ligase subunit DIA2 Neighboring gene triacylglycerol lipase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Suppression of oxidative damage by Saccharomyces cerevisiae ATX2, which encodes a manganese-trafficking protein that localizes to Golgi-like vesicles. Lin SJ, et al. Mol Cell Biol, 1996 Nov. PMID 8887660, Free PMC Article
  2. Manganese redistribution by calcium-stimulated vesicle trafficking bypasses the need for P-type ATPase function. García-Rodríguez N, et al. J Biol Chem, 2015 Apr 10. PMID 25713143, Free PMC Article
  3. Yeast Mn2+ transporter, Smf1p, is regulated by ubiquitin-dependent vacuolar protein sorting. Eguez L, et al. Genetics, 2004 May. PMID 15166140, Free PMC Article
  4. A nuclear role for the DEAD-box protein Dbp5 in tRNA export. Lari A, et al. Elife, 2019 Aug 27. PMID 31453808, Free PMC Article
  5. Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Schuldiner M, et al. Cell, 2005 Nov 4. PMID 16269340

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables manganese ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular manganese ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in manganese ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zinc ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Mn(2+) transporter ATX2
NP_014722.1
  • Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    473475..474416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183498.1 → NP_014722.1  TPA: Mn(2+) transporter ATX2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014722.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2E2, Q12067
    UniProtKB/TrEMBL
    A6ZNT1, B3LJC8, B5VRX5, C7GT36, C8ZI41, G2WMV7, N1NWX1
    Conserved Domains (1) summary
    pfam02535
    Location:4 → 306
    Zip; ZIP Zinc transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12067.1

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