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SKI7 Ski7p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854243, updated on 29-Jun-2024

Summary

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Gene symbol
SKI7
Gene description
Ski7p
Primary source
FungiDB:YOR076C
Locus tag
YOR076C
See related
SGD:S000005602; AllianceGenome:SGD:S000005602; VEuPathDB:YOR076C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTP binding activity and protein-macromolecule adaptor activity. Involved in RNA catabolic process and protein catabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SKI7 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (469377..471620, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene thymidylate synthase Neighboring gene Ufe1p Neighboring gene Rts2p Neighboring gene Bud21p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases. Kowalinski E, et al. Structure, 2015 Jul 7. PMID 26051716, Free PMC Article
  2. Crystallization and preliminary X-ray analysis of the C-terminal fragment of Ski7 from Saccharomyces cerevisiae. Lee JY, et al. Acta Crystallogr F Struct Biol Commun, 2014 Sep. PMID 25195903, Free PMC Article
  3. Translation of aberrant mRNAs lacking a termination codon or with a shortened 3'-UTR is repressed after initiation in yeast. Inada T, et al. EMBO J, 2005 Apr 20. PMID 15933721, Free PMC Article
  4. A short splicing isoform of HBS1L links the cytoplasmic exosome and SKI complexes in humans. Kalisiak K, et al. Nucleic Acids Res, 2017 Feb 28. PMID 28204585, Free PMC Article
  5. Conservation of mRNA quality control factor Ski7 and its diversification through changes in alternative splicing and gene duplication. Marshall AN, et al. Proc Natl Acad Sci U S A, 2018 Jul 17. PMID 29967155, Free PMC Article

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors report strong genetic evidence suggesting differential roles for Ski7 N-terminal and Ski7 C-terminal domains in normal and specific mRNA turnover pathways by creating/isolating mutations in conserved motifs using indicator yeast strains.
    Title: Mutations in the G-domain of Ski7 cause specific dysfunction in non-stop decay.
  2. Cytoplasmic Ski7 and nuclear Rrp6 bind Exo10 using similar surfaces and recognition motifs.
    Title: Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex.
  3. Crysta structure of Saccharomyces cerevisiae Ski7.
    Title: Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases.
  4. Ski7p interacts with the Ski complex via its interaction with Ski8p and Ski3p.
    Title: Domain interactions within the Ski2/3/8 complex and between the Ski complex and Ski7p.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-macromolecule adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in nonfunctional rRNA decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, non-stop decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
  
involved_in protein catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
Ski7p
NP_014719.1
  • GTP-binding protein that couples the Ski complex and exosome; putative pseudo-translational GTPase involved in 3'-to-5' mRNA decay pathway; interacts with both the cytoplasmic exosome and the Ski complex; eRF3-like domain targets nonstop mRNA for degradation; null mutants have a superkiller phenotype; SKI7 has a paralog, HBS1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    469377..471620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183495.1 → NP_014719.1  TPA: Ski7p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014719.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2D9, O00032, Q08491
    UniProtKB/TrEMBL
    A0A8H4F786, A6ZNS8
    Conserved Domains (1) summary
    COG5256
    Location:261 → 747
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08491.1

Gene LinkOut

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