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NRT1 nicotinamide riboside transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 854237, updated on 2-Nov-2024

Summary

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Official Symbol
NRT1
Official Full Name
nicotinamide riboside transporter
Primary source
SGD:S000005597
Locus tag
YOR071C
See related
AllianceGenome:SGD:S000005597; FungiDB:YOR071C; VEuPathDB:YOR071C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
THI71; YOR29-22
Summary
Enables 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity and nicotinamide riboside transmembrane transporter activity. Involved in 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport; nicotinamide riboside transport; and thiamine transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See NRT1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (459480..461276, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Vam10p Neighboring gene sorting nexin 1 Neighboring gene GTPase-activating protein GYP1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tRNA-Pro

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of a thiamin transport gene, THI10, from Saccharomyces cerevisiae. Enjo F, et al. J Biol Chem, 1997 Aug 1. PMID 9235906
  2. Nrt1 and Tna1-independent export of NAD+ precursor vitamins promotes NAD+ homeostasis and allows engineering of vitamin production. Belenky P, et al. PLoS One, 2011 May 11. PMID 21589930, Free PMC Article
  3. Saccharomyces cerevisiae YOR071C encodes the high affinity nicotinamide riboside transporter Nrt1. Belenky PA, et al. J Biol Chem, 2008 Mar 28. PMID 18258590
  4. Identification of yeast and human 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAr) transporters. Ceschin J, et al. J Biol Chem, 2014 Jun 13. PMID 24778186, Free PMC Article
  5. Characterization of Thi9, a novel thiamine (Vitamin B1) transporter from Schizosaccharomyces pombe. Vogl C, et al. J Biol Chem, 2008 Mar 21. PMID 18201975

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters, Thi7, Nrt1, and Thi72.
    Title: Yeast α-arrestin Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters.
  2. Nrt1-related molecules are conserved in particular fungi, suggesting a similar basis for nicotinamide riboside uptake
    Title: Saccharomyces cerevisiae YOR071C encodes the high affinity nicotinamide riboside transporter Nrt1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nicotinamide riboside transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables nicotinamide riboside transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nucleobase transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nicotinamide riboside transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nicotinamide riboside transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nitrogen compound transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleobase transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thiamine transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
nicotinamide riboside transporter
NP_014714.1
  • High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; major transporter for 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine) uptake; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    459480..461276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183490.1 → NP_014714.1  TPA: nicotinamide riboside transporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014714.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2D4, O00029, Q08485
    UniProtKB/TrEMBL
    C8ZI32, G2WMU9
    Conserved Domains (1) summary
    cd11482
    Location:27 → 505
    SLC-NCS1sbd_NRT1-like; nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08485.1

Gene LinkOut

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