Prkd1 protein kinase D1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prkd1provided by RGD
Official Full Name: protein kinase D1provided by RGD
Primary source: RGD:620964
See related: EnsemblRapid:ENSRNOG00000004165 AllianceGenome:RGD:620964
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pkcm; Prkcm; nPKC-D1; nPKC-mu
Summary: Enables heat shock protein binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular response to peptide hormone stimulus; positive regulation of macromolecule metabolic process; and positive regulation of transport. Located in several cellular components, including Z disc; nucleus; and perinuclear region of cytoplasm. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human PRKD1 (protein kinase D1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 52.3), Heart (RPKM 33.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q22

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (73460640..73774433, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (67725193..68039002, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (71035017..71349531, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of protein kinase D1 in vasoconstriction and haemodynamics in rats.
Title: Role of protein kinase D1 in vasoconstriction and haemodynamics in rats.
Protein kinase D1 promotes the survival of random-pattern skin flaps in rats.
Title: Protein kinase D1 promotes the survival of random-pattern skin flaps in rats.
The results suggest that PKD participates in the development of cardiac hypertrophy by regulating autophagy via AKT/mTOR/S6K pathway.
Title: PKD deletion promotes autophagy and inhibits hypertrophy in cardiomyocyte.
siRNA-mediated knockdown of PKD1, PKD2, and PKD3 markedly attenuated YAP nuclear-cytoplasmic shuttling, phosphorylation at Ser(127), and induction of Ctgf and Areg expression in response to GPCR activation.
Title: Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR PROTEIN KINASE D (PKD).
Study delineates the protein kinase D1 binding sites on HSP20 and shows that HSP20 is a substrate for protein kinase D1.
Title: Heat shock protein 20 (HSP20) is a novel substrate for protein kinase D1 (PKD1).
PKD1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells.
Title: Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling.
Data suggest Fhl1 (four-and-a-half LIM domains protein 1) and FHL2 (four-and-a-half LIM domains protein 2) bind to/regulate activity of Prkd1 (protein kinase D 1) in cardiac/ventricular myocytes; knockdown of Fhl1/FHL2 downregulates Prkd1 activation.
Title: Four-and-a-half LIM domains proteins are novel regulators of the protein kinase D pathway in cardiac myocytes.
Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes.
Title: Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes.
PKD facilitates contraction of cardiomyocytes by increasing Ca(2+) sensitivity and by an increased calcium-activated tension of contraction through phosphorylation of cMyBP-C.
Title: Protein kinase D increases maximal Ca2+-activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser315.
a novel contraction-induced ROS-DAPK-PKD1 pathway in cardiomyocytes
Title: Protein kinase D1 is essential for contraction-induced glucose uptake but is not involved in fatty acid uptake into cardiomyocytes.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BQ209938 (e-PCR)
- UniSTS:260639

Prkcm (e-PCR), detects polymorphism
- UniSTS:144198

UniSTS:224841 (e-PCR)
- UniSTS:224841

D6Got79 (e-PCR)
- UniSTS:113899

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase C binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Golgi organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in Golgi vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in Golgi vesicle transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to angiotensin	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to endothelin	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hydroperoxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to norepinephrine stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to organic cyclic compound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to phorbol 13-acetate 12-myristate	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vascular endothelial growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of peptide hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of keratinocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to norepinephrine	IDA Inferred from Direct Assay more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine/threonine-protein kinase D1

Names: protein kinase C mu type

NP_001263644.1

EC 2.7.11.13

NP_001399024.1

EC 2.7.11.13

XP_038968942.1

EC 2.7.11.13

XP_038968943.1

EC 2.7.11.13

XP_038968945.1

EC 2.7.11.13

XP_038968946.1

EC 2.7.11.13

XP_038968947.1

EC 2.7.11.13

XP_038968948.1

EC 2.7.11.13

XP_038968949.1

EC 2.7.11.13

XP_038968950.1

EC 2.7.11.13

XP_063118631.1

EC 2.7.11.13

XP_063118632.1

EC 2.7.11.13

XP_063118633.1

EC 2.7.11.13

XP_063118634.1

EC 2.7.11.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276715.2 → NP_001263644.1 serine/threonine-protein kinase D1 isoform 1

See identical proteins and their annotated locations for NP_001263644.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q9WTQ1

UniProtKB/TrEMBL

A6HBG5

Related

ENSRNOP00000063159.3, ENSRNOT00000068077.4

Conserved Domains (5) summary

smart00220
Location:593 → 845

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00029
Location:277 → 326

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01239
Location:422 → 549

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:585 → 844

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

pfam00130
Location:145 → 194

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001412095.1 → NP_001399024.1 serine/threonine-protein kinase D1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6A9E1

Related

ENSRNOP00000089750.2, ENSRNOT00000100654.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

73460640..73774433 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039113015.2 → XP_038968943.1 serine/threonine-protein kinase D1 isoform X2

UniProtKB/TrEMBL

A6HBG5

Conserved Domains (4) summary

cd01239
Location:414 → 541

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:587 → 846

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

cd20839
Location:138 → 209

C1_PKD1_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D (PKD) and similar proteins

cd20842
Location:235 → 328

C1_PKD1_rpt2; second protein kinase C conserved region 1 (C1 domain) found in protein kinase D (PKD) and similar proteins
XM_039113014.2 → XP_038968942.1 serine/threonine-protein kinase D1 isoform X1

UniProtKB/TrEMBL

A6HBG5

Conserved Domains (4) summary

cd01239
Location:422 → 549

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:595 → 854

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

cd20839
Location:138 → 209

C1_PKD1_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D (PKD) and similar proteins

cd20842
Location:243 → 336

C1_PKD1_rpt2; second protein kinase C conserved region 1 (C1 domain) found in protein kinase D (PKD) and similar proteins
XM_039113019.2 → XP_038968947.1 serine/threonine-protein kinase D1 isoform X4

UniProtKB/TrEMBL

A6HBG5

Conserved Domains (4) summary

cd01239
Location:380 → 507

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:553 → 812

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

cd20839
Location:96 → 167

C1_PKD1_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D (PKD) and similar proteins

cd20842
Location:201 → 294

C1_PKD1_rpt2; second protein kinase C conserved region 1 (C1 domain) found in protein kinase D (PKD) and similar proteins
XM_063262562.1 → XP_063118632.1 serine/threonine-protein kinase D1 isoform X5

UniProtKB/TrEMBL

A0A0G2K928

Related

ENSRNOP00000074836.1, ENSRNOT00000081883.3
XM_039113018.2 → XP_038968946.1 serine/threonine-protein kinase D1 isoform X4

UniProtKB/TrEMBL

A6HBG5

Conserved Domains (4) summary

cd01239
Location:380 → 507

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:553 → 812

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

cd20839
Location:96 → 167

C1_PKD1_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D (PKD) and similar proteins

cd20842
Location:201 → 294

C1_PKD1_rpt2; second protein kinase C conserved region 1 (C1 domain) found in protein kinase D (PKD) and similar proteins
XM_039113017.2 → XP_038968945.1 serine/threonine-protein kinase D1 isoform X4

UniProtKB/TrEMBL

A6HBG5

Conserved Domains (4) summary

cd01239
Location:380 → 507

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:553 → 812

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

cd20839
Location:96 → 167

C1_PKD1_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D (PKD) and similar proteins

cd20842
Location:201 → 294

C1_PKD1_rpt2; second protein kinase C conserved region 1 (C1 domain) found in protein kinase D (PKD) and similar proteins
XM_063262563.1 → XP_063118633.1 serine/threonine-protein kinase D1 isoform X7
XM_039113020.2 → XP_038968948.1 serine/threonine-protein kinase D1 isoform X6

Conserved Domains (3) summary

cd01239
Location:212 → 339

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:385 → 644

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

cd20842
Location:33 → 126

C1_PKD1_rpt2; second protein kinase C conserved region 1 (C1 domain) found in protein kinase D (PKD) and similar proteins
XM_063262564.1 → XP_063118634.1 serine/threonine-protein kinase D1 isoform X8
XM_039113021.2 → XP_038968949.1 serine/threonine-protein kinase D1 isoform X8

Conserved Domains (3) summary

cd01239
Location:153 → 280

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:326 → 585

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

cl00040
Location:1 → 67

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_039113022.2 → XP_038968950.1 serine/threonine-protein kinase D1 isoform X8

Conserved Domains (3) summary

cd01239
Location:153 → 280

PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain

cd14082
Location:326 → 585

STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D

cl00040
Location:1 → 67

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_063262561.1 → XP_063118631.1 serine/threonine-protein kinase D1 isoform X3