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PFA4 palmitoyltransferase PFA4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854159, updated on 18-Sep-2024

Summary

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Official Symbol
PFA4
Official Full Name
palmitoyltransferase PFA4
Primary source
SGD:S000005363
Locus tag
YOL003C
See related
AllianceGenome:SGD:S000005363; FungiDB:YOL003C; VEuPathDB:YOL003C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables palmitoyltransferase activity. Involved in protein palmitoylation. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 91. Orthologous to human ZDHHC15 (zinc finger DHHC-type palmitoyltransferase 15); ZDHHC2 (zinc finger DHHC-type palmitoyltransferase 2); and ZDHHC20 (zinc finger DHHC-type palmitoyltransferase 20). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PFA4 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (321858..322994, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase II core subunit RPB11 Neighboring gene transcriptional regulator SIN3 Neighboring gene PAQR-type receptor Neighboring gene Pho80p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane. Fontana GA, et al. Nat Commun, 2019 Jun 10. PMID 31182712, Free PMC Article
  2. Palmitoylation by the DHHC protein Pfa4 regulates the ER exit of Chs3. Lam KK, et al. J Cell Biol, 2006 Jul 3. PMID 16818716, Free PMC Article
  3. Specificity of transmembrane protein palmitoylation in yeast. González Montoro A, et al. PLoS One, 2011 Feb 24. PMID 21383992, Free PMC Article
  4. The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p. Smotrys JE, et al. J Cell Biol, 2005 Sep 26. PMID 16186255, Free PMC Article
  5. In Vitro and In Vivo Studies on the Structural Organization of Chs3 from Saccharomyces cerevisiae. Gohlke S, et al. Int J Mol Sci, 2017 Mar 25. PMID 28346351, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The canonical DHHC motif is not absolutely required for the activity of the yeast S-acyltransferases Swf1 and Pfa4.
    Title: The canonical DHHC motif is not absolutely required for the activity of the yeast S-acyltransferases Swf1 and Pfa4.
  2. We find that Chs3 is palmitoylated and that this modification is Pfa4-dependent, indicating that Pfa4 is indeed a protein acyl transferase.
    Title: Palmitoylation by the DHHC protein Pfa4 regulates the ER exit of Chs3.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein palmitoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein palmitoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase PFA4
NP_014640.1
  • Palmitoyltransferase with autoacylation activity; required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    321858..322994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183257.1 → NP_014640.1  TPA: palmitoyltransferase PFA4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014640.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W264, Q12006
    UniProtKB/TrEMBL
    A6ZNK3, B3LJ53, C7GJV5
    Conserved Domains (1) summary
    COG5273
    Location:1 → 344
    COG5273; Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12006.1

Gene LinkOut

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