GPD2 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GPD2
Official Full Name: glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2
Primary source: SGD:S000005420
Locus tag: YOL059W
See related: AllianceGenome:SGD:S000005420; FungiDB:YOL059W; VEuPathDB:YOL059W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GPD3
Summary: Enables glycerol-3-phosphate dehydrogenase [NAD(P)+] activity. Involved in NADH oxidation and glycerol metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Orthologous to human GPD1 (glycerol-3-phosphate dehydrogenase 1) and GPD1L (glycerol-3-phosphate dehydrogenase 1 like). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See GPD2 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (217126..218448)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylation of Gpd1 and Gpd2 by distinct kinases enables rapid adaptation to specific stress conditions in Saccharomyces cerevisiae.
Title: Reciprocal phosphorylation of yeast glycerol-3-phosphate dehydrogenases in adaptation to distinct types of stress.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADH oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in NADH oxidation	IEA Inferred from Electronic Annotation more info
involved_in NADH oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerol-3-phosphate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol-3-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2

NP_014582.1

EC 1.1.1.8

NAD-dependent glycerol 3-phosphate dehydrogenase; expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1; GPD2 has a paralog, GPD1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

217126..218448

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183314.1 → NP_014582.1 TPA: glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014582.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W208, P41911, P50905

UniProtKB/TrEMBL

A6ZNF1, B3LJ00, C7GK26, N1NVP2

Conserved Domains (1) summary

TIGR03376
Location:85 → 432

glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))