U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DNAJC14 DnaJ heat shock protein family (Hsp40) member C14 [ Homo sapiens (human) ]

Gene ID: 85406, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
DNAJC14provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member C14provided by HGNC
Primary source
HGNC:HGNC:24581
See related
Ensembl:ENSG00000135392 MIM:606092; AllianceGenome:HGNC:24581
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DNAJ; HDJ3; LIP6; DRIP78
Summary
Predicted to be involved in protein transport. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 16.8), thyroid (RPKM 12.6) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See DNAJC14 in Genome Data Viewer
Location:
12q13.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (55820985..55830775, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (55787629..55797421, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56214769..56224559, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:56122619-56123225 Neighboring gene CD63 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6459 Neighboring gene CD63 molecule Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4537 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56140299-56140802 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr12:56140803-56141306 Neighboring gene growth differentiation factor 11 Neighboring gene SAP domain containing ribonucleoprotein Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:56192003-56192504 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4538 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56223947-56224684 Neighboring gene ORMDL sphingolipid biosynthesis regulator 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6460 Neighboring gene transmembrane protein 198B (pseudogene) Neighboring gene matrix metallopeptidase 19 Neighboring gene OLA1 pseudogene 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Flavivirus replication complex assembly revealed by DNAJC14 functional mapping. Yi Z, et al. J Virol, 2012 Nov. PMID 22915803, Free PMC Article
  2. Molecular cloning and characterization of a novel human J-domain protein gene (HDJ3) from the fetal brain. Chen J, et al. J Hum Genet, 2003. PMID 12768437
  3. Chaperone-Assisted Protein Folding Is Critical for Yellow Fever Virus NS3/4A Cleavage and Replication. Bozzacco L, et al. J Virol, 2016 Jan 6. PMID 26739057, Free PMC Article
  4. Dopamine receptor-interacting protein 78 acts as a molecular chaperone for CCR5 chemokine receptor signaling complex organization. Kuang YQ, et al. PLoS One, 2012. PMID 22815758, Free PMC Article
  5. Accessory proteins in the biogenesis of G protein-coupled receptors. Bermak JC, et al. Mol Interv, 2001 Dec. PMID 14993367

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hsc70 and DNAJC14 are required for the unconventional trafficking of H723R-pendrin.
    Title: The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for unconventional protein secretion.
  2. This suggests that DNAJC14's folding activity normally modulates yellow fever virus NS3/4A/2K cleavage events to liberate appropriate levels of NS3 and NS4A and promote replication complex formation.
    Title: Chaperone-Assisted Protein Folding Is Critical for Yellow Fever Virus NS3/4A Cleavage and Replication.
  3. a molecular chaperone, DRiP78, that interacts with both CXCR4 and CCR5, but not the heterodimer formed by these receptors
    Title: Dopamine receptor-interacting protein 78 acts as a molecular chaperone for CCR5 chemokine receptor signaling complex organization.
  4. These findings support a novel model of DNAJC14 action that includes specific membrane targeting of both DNAJC14 and yellow fever virus replication proteins.
    Title: Flavivirus replication complex assembly revealed by DNAJC14 functional mapping.
  5. DNAJC14 is required for yellow fever virus replication.
    Title: Identification and characterization of the host protein DNAJC14 as a broadly active flavivirus replication modulator.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Potential readthrough

Included gene: SARNP

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dopamine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
dnaJ homolog subfamily C member 14
Names
DnaJ (Hsp40) homolog, subfamily C, member 14
LYST-interacting protein LIP6
dnaJ protein homolog 3
dopamine receptor interacting protein
dopamine receptor-interacting protein of 78 kDa
human DnaJ protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394687.1 → NP_001381616.1  dnaJ homolog subfamily C member 14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC023055
    Consensus CDS
    CCDS8894.1
    UniProtKB/Swiss-Prot
    A5YM67, Q17RY2, Q66K17, Q6Y2X3, Q96N59, Q96T63
    UniProtKB/TrEMBL
    A8K5A7
    Related
    ENSP00000448876.2, ENST00000546957.2
    Conserved Domains (2) summary
    pfam00226
    Location:443 → 504
    DnaJ; DnaJ domain
    pfam14901
    Location:532 → 620
    Jiv90; Cleavage inducing molecular chaperone

  2. NM_001394688.1 → NP_001381617.1  dnaJ homolog subfamily C member 14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC023055
    Consensus CDS
    CCDS8894.1
    UniProtKB/Swiss-Prot
    A5YM67, Q17RY2, Q66K17, Q6Y2X3, Q96N59, Q96T63
    UniProtKB/TrEMBL
    A8K5A7
    Related
    ENSP00000317500.5, ENST00000317287.5
    Conserved Domains (2) summary
    pfam00226
    Location:443 → 504
    DnaJ; DnaJ domain
    pfam14901
    Location:532 → 620
    Jiv90; Cleavage inducing molecular chaperone

  3. NM_001394689.1 → NP_001381618.1  dnaJ homolog subfamily C member 14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC023055
    Consensus CDS
    CCDS8894.1
    UniProtKB/Swiss-Prot
    A5YM67, Q17RY2, Q66K17, Q6Y2X3, Q96N59, Q96T63
    UniProtKB/TrEMBL
    A8K5A7
    Related
    ENSP00000450196.2, ENST00000547445.2
    Conserved Domains (2) summary
    pfam00226
    Location:443 → 504
    DnaJ; DnaJ domain
    pfam14901
    Location:532 → 620
    Jiv90; Cleavage inducing molecular chaperone

  4. NM_001394690.1 → NP_001381619.1  dnaJ homolog subfamily C member 14 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC023055
    UniProtKB/TrEMBL
    A8K5A7
    Conserved Domains (1) summary
    smart00271
    Location:443 → 499
    DnaJ; DnaJ molecular chaperone homology domain

  5. NM_032364.6 → NP_115740.5  dnaJ homolog subfamily C member 14 isoform 1

    See identical proteins and their annotated locations for NP_115740.5

    Status: VALIDATED

    Source sequence(s)
    AY188447, BC080655, DA127901
    Consensus CDS
    CCDS8894.1
    UniProtKB/Swiss-Prot
    A5YM67, Q17RY2, Q66K17, Q6Y2X3, Q96N59, Q96T63
    UniProtKB/TrEMBL
    A8K5A7
    Related
    ENSP00000504134.1, ENST00000678005.2
    Conserved Domains (2) summary
    pfam00226
    Location:443 → 504
    DnaJ; DnaJ domain
    pfam14901
    Location:532 → 620
    Jiv90; Cleavage inducing molecular chaperone

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    55820985..55830775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    55787629..55797421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6Y2X3.2 GenPept UniProtKB/Swiss-Prot:Q6Y2X3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous