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RIB4 lumazine synthase RIB4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854022, updated on 2-Nov-2024

Summary

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Official Symbol
RIB4
Official Full Name
lumazine synthase RIB4
Primary source
SGD:S000005503
Locus tag
YOL143C
See related
AllianceGenome:SGD:S000005503; FungiDB:YOL143C; VEuPathDB:YOL143C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 6,7-dimethyl-8-ribityllumazine synthase activity. Involved in riboflavin biosynthetic process. Located in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RIB4 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (54595..55104, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Ctr9p Neighboring gene Nop8p Neighboring gene exosome non-catalytic core subunit RRP40 Neighboring gene tRNA methyltransferase PPM2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The atomic structure of pentameric lumazine synthase from Saccharomyces cerevisiae at 1.85 A resolution reveals the binding mode of a phosphonate intermediate analogue. Meining W, et al. J Mol Biol, 2000 May 26. PMID 10860731
  2. Tunnel plasticity and quaternary structural integrity of a pentameric protein ring. Woycechowsky KJ, et al. Protein Sci, 2006 May. PMID 16641488, Free PMC Article
  3. (15)N{(31)P} REDOR NMR studies of the binding of phosphonate reaction intermediate analogues to Saccharomyces cerevisiae lumazine synthase. Yu TY, et al. Biochemistry, 2008 Dec 30. PMID 19117095, Free PMC Article
  4. Biosynthesis of riboflavin. Lumazine synthase of Escherichia coli. Mörtl S, et al. J Biol Chem, 1996 Dec 27. PMID 8969176
  5. Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors. Morgunova E, et al. Biochemistry, 2005 Mar 1. PMID 15723519

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. molecular dynamics simulations. The resulting models indicate mobility of the Lys92 side chain, which could facilitate the exchange of phosphate
    Title: (15)N{(31)P} REDOR NMR studies of the binding of phosphonate reaction intermediate analogues to Saccharomyces cerevisiae lumazine synthase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 6,7-dimethyl-8-ribityllumazine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 6,7-dimethyl-8-ribityllumazine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 6,7-dimethyl-8-ribityllumazine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in riboflavin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in riboflavin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in riboflavin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
part_of riboflavin synthase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lumazine synthase RIB4
NP_014498.1
  • Lumazine synthase (DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin; DMRL synthase stands for 6,7-dimethyl-8-ribityllumazine synthase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    54595..55104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183397.1 → NP_014498.1  TPA: lumazine synthase RIB4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014498.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1S6, P50861, Q08286
    UniProtKB/TrEMBL
    A6ZN69, B3LIS4, C7GV18, C8ZHH4, G2WM95, N1NVR4
    Conserved Domains (1) summary
    TIGR00114
    Location:18 → 164
    lumazine-synth; 6,7-dimethyl-8-ribityllumazine synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50861.2

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