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PXL1 Pxl1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853965, updated on 3-Nov-2024

Summary

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Official Symbol
PXL1
Official Full Name
Pxl1p
Primary source
SGD:S000001798
Locus tag
YKR090W
See related
AllianceGenome:SGD:S000001798; FungiDB:YKR090W; VEuPathDB:YKR090W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables Rho GDP-dissociation inhibitor activity. Involved in maintenance of cell polarity and regulation of Rho protein signal transduction. Located in several cellular components, including cellular bud tip; incipient cellular bud site; and mating projection tip. Orthologous to human LPXN (leupaxin); PXN (paxillin); and TGFB1I1 (transforming growth factor beta 1 induced transcript 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PXL1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (608946..611066)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Tvp38p Neighboring gene triacylglycerol lipase Neighboring gene DNA-binding protein SRL3 Neighboring gene Srp40p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The PXL1 gene of Saccharomyces cerevisiae encodes a paxillin-like protein functioning in polarized cell growth. Mackin NA, et al. Mol Biol Cell, 2004 Apr. PMID 14767053, Free PMC Article
  2. Pxl1p, a paxillin-like protein in Saccharomyces cerevisiae, may coordinate Cdc42p and Rho1p functions during polarized growth. Gao XD, et al. Mol Biol Cell, 2004 Sep. PMID 15215315, Free PMC Article
  3. Correcting an instance of synthetic lethality with a pro-survival sequence. Zhou DR, et al. Biochim Biophys Acta Mol Cell Res, 2020 Sep. PMID 32389645
  4. Multi-gene phylogenetic analysis reveals that shochu-fermenting Saccharomyces cerevisiae strains form a distinct sub-clade of the Japanese sake cluster. Futagami T, et al. Yeast, 2017 Oct. PMID 28703391
  5. Involvement of the mitochondrial retrograde pathway in dihydrosphingosine-induced cytotoxicity in budding yeast. Takayama C, et al. Biochem Biophys Res Commun, 2022 May 21. PMID 35316765

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In this study, the authors performed the first phylogenetic classification of shochu strains using the nucleotide sequences of genes that reflect genome-level phylogeny. The single-nucleotide polymorphisms information identified in the present study is expected to be useful for distinguishing shochu yeast strains as part of quality control at shochu breweries.
    Title: Multi-gene phylogenetic analysis reveals that shochu-fermenting Saccharomyces cerevisiae strains form a distinct sub-clade of the Japanese sake cluster.
  2. The opposite effects of overexpressed Pxl1p on cdc42 and rho1 mutants suggest that the functions of Cdc42p and Rho1p may be coordinately regulated during budding and that Pxl1p may be involved in this coordination.
    Title: Pxl1p, a paxillin-like protein in Saccharomyces cerevisiae, may coordinate Cdc42p and Rho1p functions during polarized growth.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho GDP-dissociation inhibitor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Rho protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of Rho protein signal transduction IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud HDA PubMed 
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip HDA PubMed 
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in site of polarized growth IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Pxl1p
NP_013016.4
  • Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    608946..611066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179880.4 → NP_013016.4  TPA: Pxl1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013016.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXF0, P36166
    UniProtKB/TrEMBL
    A7A049
    Conserved Domains (2) summary
    cd09397
    Location:556 → 614
    LIM1_UF1; LIM domain in proteins of unknown function
    cd08368
    Location:621 → 672
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36166.3

Gene LinkOut

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