CCP1 cytochrome-c peroxidase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CCP1
Official Full Name: cytochrome-c peroxidase
Primary source: SGD:S000001774
Locus tag: YKR066C
See related: AllianceGenome:SGD:S000001774; FungiDB:YKR066C; VEuPathDB:YKR066C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables cytochrome-c peroxidase activity. Involved in cellular response to oxidative stress. Located in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CCP1 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (566113..567198, complement)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhancing the population of the encounter complex affects protein complex formation efficiency.
Title: Enhancing the population of the encounter complex affects protein complex formation efficiency.
Yeast cytochrome c (y-cytc) contains a substantial expanded state in its native folded condition, which is present in equilibrium with a compact conformer in aqueous buffer.
Title: Molecular Crowding Affects the Conformational Fluctuations, Peroxidase Activity, and Folding Landscape of Yeast Cytochrome c.
The current study is consistent with a model for yCc binding to CcP in which yCc binds predominantly near the region defined by crystallographic structure of the 1:1 yCc-CcP complex
Title: Binding of Yeast Cytochrome c to Forty-Four Charge-Reversal Mutants of Yeast Cytochrome c Peroxidase: Isothermal Titration Calorimetry.
yCcP has a four-fold increase in 1-methylimidazole binding affinity on decreasing the pH from 7.5 to 4.0, an observation that is unique among the many studies on binding of imidazole and imidazole derivatives to heme proteins.
Title: Binding of imidazole, 1-methylimidazole and 4-nitroimidazole to yeast cytochrome c peroxidase (CcP) and the distal histidine mutant, CcP(H52L).
The CcP triple mutants have higher binding affinities for 1-methylimidazole and 4-nitroimidazole than does wild-type CcP.
Title: Apolar distal pocket mutants of yeast cytochrome c peroxidase: Binding of imidazole, 1-methylimidazole and 4-nitroimidazole to the triAla, triVal, and triLeu variants.
our results strongly implicate Ccp1, independent of its peroxidase activity, in mitochondrial H2O2 sensing and signaling to maintain reactive oxygen species homeostasis
Title: Cytochrome c peroxidase is a mitochondrial heme-based H2O2 sensor that modulates antioxidant defense.
Ccp1 responds to respiration-derived H2O2 via a previously unidentified mechanism involving H2O2-activated heme transfer to apoCta1
Title: Respiration triggers heme transfer from cytochrome c peroxidase to catalase in yeast mitochondria.
Control of cyclic photoinitiated electron transfer between cytochrome c peroxidase (W191F) and cytochrome c by formation of dynamic binary and ternary complexes.
Title: Control of cyclic photoinitiated electron transfer between cytochrome c peroxidase (W191F) and cytochrome c by formation of dynamic binary and ternary complexes.
Horse Cc binds CcP but forms a much more dynamic complex. A single conservative mutation of Lys-13 to ARG reduces the dynamics and enhances the specificity. The K13A mutation of Cc increases the dynamic nature of the complex with CcP.
Title: Engineering specificity in a dynamic protein complex with a single conserved mutation.
Cofactor-dependent structural and binding properties of yeast cytochrome C peroxidase.
Title: Cofactor-dependent structural and binding properties of yeast cytochrome C peroxidase.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables cytochrome-c peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cytochrome-c peroxidase activity	IEA Inferred from Electronic Annotation more info
enables cytochrome-c peroxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in response to reactive oxygen species	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome-c peroxidase

NP_012992.1

EC 1.11.1.5

Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria; acts as hydrogen peroxide sensor in mitochondria, involved in the response to oxidative stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

566113..567198 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179856.1 → NP_012992.1 TPA: cytochrome-c peroxidase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012992.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXC7, P00431, Q6Q5M9

UniProtKB/TrEMBL

C7GX73

Conserved Domains (1) summary

cl00196
Location:13 → 361

plant_peroxidase_like; Heme-dependent peroxidases similar to plant peroxidases