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UTH1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853916, updated on 22-Aug-2024

Summary

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Official Symbol
UTH1
Primary source
FungiDB:YKR042W
Locus tag
YKR042W
See related
SGD:S000001750; AllianceGenome:SGD:S000001750; VEuPathDB:YKR042W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable hydrolase activity, acting on glycosyl bonds. Involved in autophagy of mitochondrion and fungal-type cell wall biogenesis. Is extrinsic component of mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (519527..520624)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene tRNA-Ala Neighboring gene uncharacterized protein Neighboring gene sedoheptulose-bisphosphatase Neighboring gene Uip5p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene. Weng Y, et al. Bioorg Med Chem, 2010 Feb. PMID 20093034
  2. The SUN41 and SUN42 genes are essential for cell separation in Candida albicans. Firon A, et al. Mol Microbiol, 2007 Dec. PMID 18001349
  3. Evaluation of the roles of apoptosis, autophagy, and mitophagy in the loss of plating efficiency induced by Bax expression in yeast. Kissová I, et al. J Biol Chem, 2006 Nov 24. PMID 16990272
  4. Uth1p: a yeast mitochondrial protein at the crossroads of stress, degradation and cell death. Camougrand N, et al. FEMS Yeast Res, 2004 Nov. PMID 15489196
  5. Uth1p is involved in the autophagic degradation of mitochondria. Kissová I, et al. J Biol Chem, 2004 Sep 10. PMID 15247238

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dynamic post-transcriptional regulation by Mrn1 links cell wall homeostasis to mitochondrial structure and function.
    Title: Dynamic post-transcriptional regulation by Mrn1 links cell wall homeostasis to mitochondrial structure and function.
  2. SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level.
    Title: SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level.
  3. re-evaluation of its mitochondrial localization revealed that Uth1 is a protein of the inner mitochondrial membrane that is targeted by a cleavable N-terminal pre-sequence
    Title: Uth1 is a mitochondrial inner membrane protein dispensable for post-log-phase and rapamycin-induced mitophagy.
  4. UTH1 is a yeast aging gene that has been identified on the basis of stress resistance and longer life span of mutants.
    Title: Uth1p: a yeast mitochondrial protein at the crossroads of stress, degradation and cell death.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in division septum assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in fungal-type cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fungal-type cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in polysaccharide catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in fungal-type cell wall IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SUN family protein UTH1
NP_012968.4
  • Mitochondrial inner membrane protein; role in mitophagy is disputed; implicated in cell wall biogenesis, the oxidative stress response, life span during starvation, and cell death; SUN family member; UTH1 has a paralog, NCA3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    519527..520624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179832.3 → NP_012968.4  TPA: SUN family protein UTH1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012968.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXA4, P36135
    UniProtKB/TrEMBL
    G2WI71, N1P0X3
    Conserved Domains (1) summary
    pfam03856
    Location:111 → 352
    SUN; Beta-glucosidase (SUN family)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36135.2

Gene LinkOut

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