HIR3 Hir3p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: HIR3
Official Full Name: Hir3p
Primary source: SGD:S000003901
Locus tag: YJR140C
See related: AllianceGenome:SGD:S000003901; FungiDB:YJR140C; VEuPathDB:YJR140C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: HPC1
Summary: Enables transcription corepressor activity. Contributes to DNA binding activity and nucleosome binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; negative regulation of transcription by RNA polymerase II; and transcription elongation by RNA polymerase II. Located in nucleus. Part of HIR complex. [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to nucleosome binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription elongation by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of HIR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of HIR complex	IDA Inferred from Direct Assay more info	PubMed
part_of HIR complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_012674.1

Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein