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MNS1 mannosyl-oligosaccharide 1,2-alpha-mannosidase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853595, updated on 18-Sep-2024

Summary

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Official Symbol
MNS1
Official Full Name
mannosyl-oligosaccharide 1,2-alpha-mannosidase
Primary source
SGD:S000003892
Locus tag
YJR131W
See related
AllianceGenome:SGD:S000003892; FungiDB:YJR131W; VEuPathDB:YJR131W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in protein deglycosylation involved in glycoprotein catabolic process and ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to several human genes including MAN1B1 (mannosidase alpha class 1B member 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MNS1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (667644..669293)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene protein-lysine N-methyltransferase Neighboring gene cystathionine gamma-synthase Neighboring gene Nmd5p Neighboring gene xanthine phosphoribosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutation of Arg(273) to Leu alters the specificity of the yeast N-glycan processing class I alpha1,2-mannosidase. Romero PA, et al. J Biol Chem, 2000 Apr 14. PMID 10753911
  2. Calcium binding to the class I alpha-1,2-mannosidase from Saccharomyces cerevisiae occurs outside the EF hand motif. Lipari F, et al. Biochemistry, 1999 Jan 19. PMID 9894008
  3. Role of the cysteine residues in the alpha1,2-mannosidase involved in N-glycan biosynthesis in Saccharomyces cerevisiae. The conserved Cys340 and Cys385 residues form an essential disulfide bond. Lipari F, et al. J Biol Chem, 1996 Nov 1. PMID 8910350
  4. The Saccharomyces cerevisiae processing alpha 1,2-mannosidase is localized in the endoplasmic reticulum, independently of known retrieval motifs. Burke J, et al. Eur J Cell Biol, 1996 Aug. PMID 8864657
  5. Disruption of the processing alpha-mannosidase gene does not prevent outer chain synthesis in Saccharomyces cerevisiae. Puccia R, et al. Biochem J, 1993 Feb 15. PMID 8439291, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of an Htm1 (EDEM)-dependent, Mns1-independent Endoplasmic Reticulum-associated Degradation (ERAD) pathway in Saccharomyces cerevisiae
    Title: Identification of an Htm1 (EDEM)-dependent, Mns1-independent Endoplasmic Reticulum-associated Degradation (ERAD) pathway in Saccharomyces cerevisiae: application of a novel assay for glycoprotein ERAD.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deglycosylation involved in glycoprotein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mannosyl-oligosaccharide 1,2-alpha-mannosidase
NP_012665.3
  • Alpha-1,2-mannosidase; involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    667644..669293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181789.3 → NP_012665.3  TPA: mannosyl-oligosaccharide 1,2-alpha-mannosidase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012665.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWU9, P32906
    UniProtKB/TrEMBL
    A6ZQ86, B3LQL3, B5VLS0, C7GM82, C8ZBS9, N1P1S7
    Conserved Domains (1) summary
    pfam01532
    Location:45 → 532
    Glyco_hydro_47; Glycosyl hydrolase family 47
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32906.1

Gene LinkOut

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