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PXP2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853575, updated on 22-Aug-2024

Summary

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Official Symbol
PXP2
Primary source
FungiDB:YJR111C
Locus tag
YJR111C
See related
SGD:S000003872; AllianceGenome:SGD:S000003872; VEuPathDB:YJR111C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable peroxiredoxin activity. Predicted to be involved in cellular oxidant detoxification. Located in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PXP2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (635855..636706, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2 Neighboring gene phosphatidylinositol-3-phosphatase YMR1 Neighboring gene MIND complex subunit NNF1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of New Fungal Peroxisomal Matrix Proteins and Revision of the PTS1 Consensus. Nötzel C, et al. Traffic, 2016 Oct. PMID 27392156
  2. Peroxisomal targeting of a protein phosphatase type 2C via mitochondrial transit. Stehlik T, et al. Nat Commun, 2020 May 12. PMID 32398688, Free PMC Article
  3. Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale. Morgenstern M, et al. Cell Rep, 2017 Jun 27. PMID 28658629, Free PMC Article
  4. Chemical-genetic profile analysis of five inhibitory compounds in yeast. Alamgir M, et al. BMC Chem Biol, 2010 Aug 6. PMID 20691087, Free PMC Article
  5. Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae. Iacovella MG, et al. Nucleic Acids Res, 2018 Sep 6. PMID 30011030, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in peroxisomal matrix IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pxp2p
NP_012645.1
  • Peroxisomal matrix protein with naturally active promoter; well-conserved in fungi; localized to peroxisomes under physiological growth conditions; levels of some amino acids are altered upon both knockout and overexpression, suggesting potential involvement of Pxp2p in amino acid metabolism or related cellular metabolic processes (needs further study); GFP-fusion protein displays inherent dual localization with large proportion localizing to cytosol

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    635855..636706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181769.1 → NP_012645.1  TPA: Pxp2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012645.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWT0, P47148
    UniProtKB/TrEMBL
    A6ZQ67, B3LQJ5, B5VLQ5, C7GM98, C8ZBQ9, G2WHB4, N1P8V3
    Conserved Domains (1) summary
    pfam02627
    Location:214 → 282
    CMD; Carboxymuconolactone decarboxylase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47148.1

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