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URA8 CTP synthase URA8 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853567, updated on 14-Nov-2024

Summary

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Official Symbol
URA8
Official Full Name
CTP synthase URA8
Primary source
SGD:S000003864
Locus tag
YJR103W
See related
AllianceGenome:SGD:S000003864; FungiDB:YJR103W; VEuPathDB:YJR103W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables CTP synthase activity. Involved in CTP biosynthetic process. Located in cytoophidium. Human ortholog(s) of this gene implicated in immunodeficiency 24. Orthologous to human CTPS1 (CTP synthase 1) and CTPS2 (CTP synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See URA8 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (620754..622490)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein RSM26 Neighboring gene ESCRT-II subunit protein VPS25 Neighboring gene superoxide dismutase SOD1 Neighboring gene adenosine kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential biochemical regulation of the URA7- and URA8-encoded CTP synthetases from Saccharomyces cerevisiae. Nadkarni AK, et al. J Biol Chem, 1995 Oct 20. PMID 7559626
  2. Regulation of phospholipid biosynthesis in Saccharomyces cerevisiae by CTP. McDonough VM, et al. J Biol Chem, 1995 Aug 11. PMID 7642527
  3. Phosphorylation of CTP synthetase from Saccharomyces cerevisiae by protein kinase C. Yang WL, et al. J Biol Chem, 1995 Jun 23. PMID 7797479, Free PMC Article
  4. Use of synthetic lethal mutants to clone and characterize a novel CTP synthetase gene in Saccharomyces cerevisiae. Ozier-Kalogeropoulos O, et al. Mol Gen Genet, 1994 Feb. PMID 8121398
  5. Phosphorylation of CTP synthetase on Ser36, Ser330, Ser354, and Ser454 regulates the levels of CTP and phosphatidylcholine synthesis in Saccharomyces cerevisiae. Park TS, et al. J Biol Chem, 2003 Jun 6. PMID 12670958

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CTP synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CTP synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables CTP synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables CTP synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in CTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CTP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoophidium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoophidium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole HDA PubMed 

General protein information

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Preferred Names
CTP synthase URA8
NP_012637.4
  • Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    620754..622490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181761.4 → NP_012637.4  TPA: CTP synthase URA8 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012637.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZQ59, D6VWS2, P38627
    UniProtKB/TrEMBL
    N1P3L8
    Conserved Domains (1) summary
    TIGR00337
    Location:1 → 557
    PyrG; CTP synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38627.4

Gene LinkOut

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