uncharacterized protein [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Full Name: uncharacterized protein
Primary source: SGD:S000003844
Locus tag: YJR084W
See related: AllianceGenome:SGD:S000003844; FungiDB:YJR084W; VEuPathDB:YJR084W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CSN12
Summary: Predicted to enable RNA binding activity and double-stranded DNA binding activity. Involved in adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion and mRNA splicing, via spliceosome. Colocalizes with transcriptionally active chromatin. Orthologous to human PCID2 (PCI domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

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role in transcription elongation for Ypr045c (Thp3) and the Csn12 component of the COP9 signalosome
Title: New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cellular response to pheromone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of COP9 signalosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_012617.1

Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome

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The following sections contain reference sequences that belong to a specific genome build. Explain