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TOH1 Toh1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853268, updated on 2-Nov-2024

Summary

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Official Symbol
TOH1
Official Full Name
Toh1p
Primary source
SGD:S000003707
Locus tag
YJL171C
See related
AllianceGenome:SGD:S000003707; FungiDB:YJL171C; VEuPathDB:YJL171C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable hydrolase activity, acting on glycosyl bonds. Predicted to be involved in cell wall organization. Located in fungal-type cell wall. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TOH1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (99704..100894, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Rfa3p Neighboring gene Gly-Xaa carboxypeptidase Neighboring gene Asg7p Neighboring gene histone methyltransferase SET2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Amyloid properties of the yeast cell wall protein Toh1 and its interaction with prion proteins Rnq1 and Sup35. Sergeeva AV, et al. Prion, 2019 Jan. PMID 30558459, Free PMC Article
  2. Screening for glycosylphosphatidylinositol (GPI)-dependent cell wall proteins in Saccharomyces cerevisiae. Hamada K, et al. Mol Gen Genet, 1998 Apr. PMID 9613572
  3. Beneficial Mutations from Evolution Experiments Increase Rates of Growth and Fermentation. Sezmis AL, et al. J Mol Evol, 2018 Feb. PMID 29349600
  4. Genome-wide analysis of the response to cell wall mutations in the yeast Saccharomyces cerevisiae. Lagorce A, et al. J Biol Chem, 2003 May 30. PMID 12644457
  5. The global transcriptional response to transient cell wall damage in Saccharomyces cerevisiae and its regulation by the cell integrity signaling pathway. García R, et al. J Biol Chem, 2004 Apr 9. PMID 14739279

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in fungal-type cell wall IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type cell wall IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in plasma membrane HDA PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Toh1p
NP_012364.2
  • GPI-anchored cell wall hypothetical protein; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    99704..100894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181604.2 → NP_012364.2  TPA: Toh1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012364.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW17, P46992
    UniProtKB/TrEMBL
    A6ZQG2, B3LPV3, C7GRZ8, C8ZB48, G2WGK3, N1P1E2
    Conserved Domains (2) summary
    pfam10287
    Location:107 → 336
    DUF2401; Putative TOS1-like glycosyl hydrolase (DUF2401)
    pfam10290
    Location:27 → 90
    DUF2403; Glycine-rich protein domain (DUF2403)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46992.2

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