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SCW4 putative family 17 glucosidase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853196, updated on 2-Nov-2024

Summary

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Official Symbol
SCW4
Official Full Name
putative family 17 glucosidase
Primary source
SGD:S000003511
Locus tag
YGR279C
See related
AllianceGenome:SGD:S000003511; FungiDB:YGR279C; VEuPathDB:YGR279C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA binding activity. Involved in conjugation with cellular fusion. Located in extracellular region; fungal-type cell wall; and vacuole. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SCW4 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (1048798..1049958, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene putative pantetheine-phosphate adenylyltransferase Neighboring gene U2-type spliceosomal complex subunit CWC22 Neighboring gene telomerase inhibitor Neighboring gene ATP-binding cassette transporter YOR1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Post-Translational Modifications, Localization, and Mode of Attachment of Non-Covalently Bound Glucanosyltransglycosylases of Yeast Cell Wall as a Key to Understanding their Functioning. Rekstina VV, et al. Int J Mol Sci, 2020 Nov 5. PMID 33167499, Free PMC Article
  2. Adhesion to the yeast cell surface as a mechanism for trapping pathogenic bacteria by Saccharomyces probiotics. Tiago FCP, et al. J Med Microbiol, 2012 Sep. PMID 22580913
  3. New potential cell wall glucanases of Saccharomyces cerevisiae and their involvement in mating. Cappellaro C, et al. J Bacteriol, 1998 Oct. PMID 9748433, Free PMC Article
  4. A model for cell wall dissolution in mating yeast cells: polarized secretion and restricted diffusion of cell wall remodeling enzymes induces local dissolution. Huberman LB, et al. PLoS One, 2014. PMID 25329559, Free PMC Article
  5. Scw10p, a cell-wall glucanase/transglucosidase important for cell-wall stability in Saccharomyces cerevisiae. Sestak S, et al. Microbiology (Reading), 2004 Oct. PMID 15470100

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proteolytic processing by Kex2 of the Saccharomyces cerevisiae cell wall protein Scw4 regulates its activity and influences its covalent binding to glucan.
    Title: Proteolytic processing of the Saccharomyces cerevisiae cell wall protein Scw4 regulates its activity and influences its covalent binding to glucan.
  2. Sec14 function was required for the route followed by Bgl2, whereas trafficking of other secreted proteins, including Hsp150, Cts1, Scw4, Scw10, Exg1, Cis3, and Ygp1, still occurred, indicating Sec14 regulates specific trans-Golgi export pathways.
    Title: Phospholipid transfer protein Sec14 is required for trafficking from endosomes and regulates distinct trans-Golgi export pathways.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glucan endo-1,3-beta-D-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucosidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in conjugation with cellular fusion IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in fungal-type cell wall IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type cell wall IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type cell wall IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole HDA PubMed 
located_in vacuole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative family 17 glucosidase
NP_011795.1
  • Cell wall protein with similarity to glucanases; targeted to vacuole via AP-3 pathway; scw4 scw10 double mutants exhibit defects in mating; SCW4 has a paralog, SCW10, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    1048798..1049958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181408.1 → NP_011795.1  TPA: putative family 17 glucosidase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011795.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV56, P53334
    UniProtKB/TrEMBL
    A6ZUT5, C7GNF6, G2WF02, N1P465
    Conserved Domains (1) summary
    COG5309
    Location:123 → 386
    Scw11; Exo-beta-1,3-glucanase, GH17 family [Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53334.1

Gene LinkOut

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