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KRTAP2-4 keratin associated protein 2-4 [ Homo sapiens (human) ]

Gene ID: 85294, updated on 7-Apr-2024

Summary

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Official Symbol
KRTAP2-4provided by HGNC
Official Full Name
keratin associated protein 2-4provided by HGNC
Primary source
HGNC:HGNC:18891
See related
Ensembl:ENSG00000213417 AllianceGenome:HGNC:18891
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAP2.3; KAP2.4; KAP2.1B; KRTAP2-3; KRTAP2.3; KRTAP2.4
Summary
This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008]
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Genomic context

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Location:
17q21.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (41065116..41065879, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (41929731..41930494, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39221368..39222131, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin associated protein 2-2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39215536-39216110 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39216111-39216685 Neighboring gene keratin associated protein 2-3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39221327-39221864 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39221865-39222401 Neighboring gene keratin associated protein 2-5, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39240697-39241226 Neighboring gene keratin associated protein 4-7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21. Rogers MA, et al. J Biol Chem, 2001 Jun 1. PMID 11279113
  2. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Yang X, et al. Cell, 2016 Feb 11. PMID 26871637, Free PMC Article
  4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC74790, MGC119882, MGC119884, MGC119885

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
keratin-associated protein 2-4
Names
Keratin-associated protein 2-3
Keratin-associated protein 2.3
high sulfur keratin-associated protein 2.4
keratin associated protein 2.1B
keratin-associated protein 2.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033184.4 → NP_149440.1  keratin-associated protein 2-4

    See identical proteins and their annotated locations for NP_149440.1

    Status: REVIEWED

    Source sequence(s)
    AJ406930
    Consensus CDS
    CCDS32648.1
    UniProtKB/Swiss-Prot
    P0C7H8, Q495J2, Q9BYR9
    Related
    ENSP00000377583.2, ENST00000394015.3
    Conserved Domains (2) summary
    pfam01500
    Location:2 → 128
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam13885
    Location:73 → 117
    Keratin_B2_2; Keratin, high sulfur B2 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    41065116..41065879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791801.1 Reference GRCh38.p14 PATCHES

    Range
    14919..15682 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003871091.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    214614..215377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    41929731..41930494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BYR9.1 GenPept UniProtKB/Swiss-Prot:Q9BYR9

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