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MPS2 Mps2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852805, updated on 2-Nov-2024

Summary

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Official Symbol
MPS2
Official Full Name
Mps2p
Primary source
SGD:S000003043
Locus tag
YGL075C
See related
AllianceGenome:SGD:S000003043; FungiDB:YGL075C; VEuPathDB:YGL075C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MMC1
Summary
Enables cytoskeleton-nuclear membrane anchor activity. Involved in several processes, including meiotic telomere tethering at nuclear periphery; protein localization to spindle pole body; and spindle pole body duplication. Located in nuclear outer membrane and spindle pole body. Part of meiotic nuclear membrane microtubule tethering complex. Is active in chromosome, telomeric region. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MPS2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (366925..368088, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L7A Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene stress-responsive transcription factor HSF1 Neighboring gene DNA-binding transcription factor AFT1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spindle pole body duplication defective yeast cells are more prone to membrane damage. Konuk HB, et al. Mycologia, 2019 Nov-Dec. PMID 31596181
  2. MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication. Winey M, et al. J Cell Biol, 1991 Aug. PMID 1869587, Free PMC Article
  3. The role of gene dosage in budding yeast centrosome scaling and spontaneous diploidization. Chen J, et al. PLoS Genet, 2020 Dec. PMID 33332348, Free PMC Article
  4. Saccharomyces cerevisiae MPS2 encodes a membrane protein localized at the spindle pole body and the nuclear envelope. Muñoz-Centeno MC, et al. Mol Biol Cell, 1999 Jul. PMID 10397772, Free PMC Article
  5. Requirement for Bbp1p in the proper mitotic functions of Cdc5p in Saccharomyces cerevisiae. Park CJ, et al. Mol Biol Cell, 2004 Apr. PMID 14767068, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast.
    Title: Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast.
  2. Mps2-Bbp1 directly interacts with Mps3 and Ndc1. We then purified Spc29 and reconstituted the ternary Mps2-Bbp1-Spc29 complex, proving that Bbp1 can simultaneously interact with Mps2 and Spc29 and in this way link the central plaque of the spindle pole body to the nuclear envelope
    Title: A ternary membrane protein complex anchors the spindle pole body in the nuclear envelope in budding yeast.
  3. Mps2p-Bbp1p complex in the spindle pole body.
    Title: The Saccharomyces cerevisiae spindle pole body (SPB) component Nbp1p is required for SPB membrane insertion and interacts with the integral membrane proteins Ndc1p and Mps2p.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cytoskeleton-nuclear membrane anchor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytoskeleton-nuclear membrane anchor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in karyogamy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic telomere tethering at nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to spindle pole body IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to spindle pole body IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle pole body duplication IEA
Inferred from Electronic Annotation
more info
  
involved_in spindle pole body duplication IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in spindle pole body duplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
part_of meiotic nuclear membrane microtubule tethering complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of meiotic nuclear membrane microtubule tethering complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole body IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mps2p
NP_011440.1
  • Essential membrane protein localized at nuclear envelope and SPBs; required for insertion of the newly duplicated spindle pole body into the nuclear envelope; potentially phosphorylated by Cdc28p; MPS2 has a paralog, CSM4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    366925..368088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180940.1 → NP_011440.1  TPA: Mps2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011440.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZUA4, C7GW39, C8Z8H2, D6VU69, E7KCH6, E7KNG0, E7LUD2, E7NHN2, E7Q3U9, E7QET1, P53159
    UniProtKB/TrEMBL
    N1P5G8
    Conserved Domains (1) summary
    pfam17060
    Location:10 → 386
    MPS2; Monopolar spindle protein 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53159.1

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