U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MF(ALPHA)2 Mf(Alpha)2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852791, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
MF(ALPHA)2
Official Full Name
Mf(Alpha)2p
Primary source
SGD:S000003057
Locus tag
YGL089C
See related
AllianceGenome:SGD:S000003057; FungiDB:YGL089C; VEuPathDB:YGL089C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cupric ion binding activity and mating pheromone activity. Involved in pheromone-dependent signal transduction involved in conjugation with cellular fusion. Located in fungal-type vacuole. [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MF(ALPHA)2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (344791..345153, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Fe-S cluster-binding ATPase Neighboring gene Lif1p Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene E2 ubiquitin-conjugating protein MMS2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Biological activity and conformational isomerism in position 9 analogues of the des-1-tryptophan,3-beta-cyclohexylalanine-alpha-factor from Saccharomyces cerevisiae. Shenbagamurthi P, et al. Biochemistry, 1985 Dec 3. PMID 3910095
  2. Biological activity of the Asn-5,Arg-7 tridecapeptide encoded by MF alpha 2 of Saccharomyces cerevisiae. Raths S, et al. J Bacteriol, 1986 Dec. PMID 3536883, Free PMC Article
  3. Prepro-alpha-factor has a cleavable signal sequence. Waters MG, et al. J Biol Chem, 1988 May 5. PMID 3283123
  4. Interactions of α-Factor-1, a Yeast Pheromone, and Its Analogue with Copper(II) Ions and Low-Molecular-Weight Ligands Yield Very Stable Complexes. Bossak K, et al. Inorg Chem, 2016 Aug 15. PMID 27476515
  5. Molecular characterization of Saccharomyces cerevisiae α-pheromone by mass spectrometry-based peptidomics. Bener Aksam E, et al. FEMS Yeast Res, 2013 May. PMID 23368790

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. determined the effects of transcriptional repressor alpha2 concentration on promoter occupancy.
    Title: A ubiquitin-selective AAA-ATPase mediates transcriptional switching by remodelling a repressor-promoter DNA complex.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cupric ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mating pheromone activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mating pheromone activity IEA
Inferred from Electronic Annotation
more info
  
enables mating pheromone activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pheromone activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mating IEA
Inferred from Electronic Annotation
more info
  
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sexual reproduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
 PubMed 
located_in fungal-type vacuole HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Mf(Alpha)2p
NP_011426.1
  • Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed; binds copper(II) ions

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    344791..345153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180954.1 → NP_011426.1  TPA: Mf(Alpha)2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011426.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU56, P32435
    UniProtKB/TrEMBL
    A6ZU91, B3LHF4, C7GW29, C8Z8F9, G2WE11, N1P356, U3N160, U3N2M0
    Conserved Domains (2) summary
    pfam04648
    Location:87 → 99
    MF_alpha; Yeast mating factor alpha hormone
    pfam05436
    Location:1 → 80
    MF_alpha_N; Mating factor alpha precursor N-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32435.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools