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SCS3 Scs3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852751, updated on 2-Nov-2024

Summary

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Official Symbol
SCS3
Official Full Name
Scs3p
Primary source
SGD:S000003094
Locus tag
YGL126W
See related
AllianceGenome:SGD:S000003094; FungiDB:YGL126W; VEuPathDB:YGL126W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FIT2B
Summary
Predicted to enable coenzyme A diphosphatase activity. Involved in phospholipid biosynthetic process. Acts upstream of or within phospholipid homeostasis. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Siddiqi syndrome. Orthologous to human FITM1 (fat storage inducing transmembrane protein 1) and FITM2 (fat storage inducing transmembrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SCS3 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (270997..272139)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene U2-type spliceosomal complex subunit CWC23 Neighboring gene mediator complex subunit SOH1 Neighboring gene methylenetetrahydrofolate reductase (NAD(P)H) MET13 Neighboring gene Mon1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and sequence of the SCS3 gene which is required for inositol prototrophy in Saccharomyces cerevisiae. Hosaka K, et al. J Biochem, 1994 Dec. PMID 7706223
  2. SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR. Moir RD, et al. PLoS Genet, 2012 Aug. PMID 22927826, Free PMC Article
  3. Fat storage-inducing transmembrane (FIT or FITM) proteins are related to lipid phosphatase/phosphotransferase enzymes. Hayes M, et al. Microb Cell, 2017 Dec 28. PMID 29417057, Free PMC Article
  4. FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis. Becuwe M, et al. J Cell Biol, 2020 Oct 5. PMID 32915949, Free PMC Article
  5. The surface of lipid droplets constitutes a barrier for endoplasmic reticulum-resident integral membrane proteins. Khaddaj R, et al. J Cell Sci, 2022 Mar 1. PMID 34028531

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis.
    Title: FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis.
  2. Study shows that SCS3 and YFT2 have shared and unique functions that connect major biosynthetic processes critical for cell growth.
    Title: SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables coenzyme A diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables coenzyme A diphosphatase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty-acyl-CoA catabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in lipid droplet formation IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid droplet organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid storage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid storage IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phospholipid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Scs3p
NP_011389.3
  • Protein required for normal ER membrane biosynthesis in response to ER stress; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis; human homolog FIT2/FITM2, a fatty acyl-CoA diphosphatase, complements the yeast null mutant; disputed role in the synthesis of inositol phospholipids from inositol; required for inositol prototrophy

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    270997..272139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180991.3 → NP_011389.3  TPA: Scs3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011389.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU22, E9P8W2, P53012
    UniProtKB/TrEMBL
    A6ZU56, B3LHI6, C7GX61, C8Z8C4, N1P3F4
    Conserved Domains (1) summary
    pfam10261
    Location:38 → 370
    Scs3p; Inositol phospholipid synthesis and fat-storage-inducing TM
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53012.1

Gene LinkOut

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