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COS12 Cos12p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852628, updated on 2-Nov-2024

Summary

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Official Symbol
COS12
Official Full Name
Cos12p
Primary source
SGD:S000003232
Locus tag
YGL263W
See related
AllianceGenome:SGD:S000003232; FungiDB:YGL263W; VEuPathDB:YGL263W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to be involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Located in fungal-type vacuole. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See COS12 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (2790..3932)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene seripauperin PAU11

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Barcode Sequencing Screen Identifies SUB1 as a Regulator of Yeast Pheromone Inducible Genes. Sliva A, et al. G3 (Bethesda), 2016 Apr 7. PMID 26837954, Free PMC Article
  2. ATF/CREB sites present in sub-telomeric regions of Saccharomyces cerevisiae chromosomes are part of promoters and act as UAS/URS of highly conserved COS genes. Spode I, et al. J Mol Biol, 2002 May 31. PMID 12051917
  3. An evolutionary scenario for one of the largest yeast gene families. Despons L, et al. Trends Genet, 2006 Jan. PMID 16269202
  4. ATP-binding cassette transporters and sterol O-acyltransferases interact at membrane microdomains to modulate sterol uptake and esterification. Gulati S, et al. FASEB J, 2015 Nov. PMID 26220175, Free PMC Article
  5. Set4 regulates stress response genes and coordinates histone deacetylases within yeast subtelomeres. Jethmalani Y, et al. Life Sci Alliance, 2021 Dec. PMID 34625508, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cos12p
NP_011251.1
  • Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    2790..3932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181129.1 → NP_011251.1  TPA: Cos12p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011251.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV71, P53053
    UniProtKB/TrEMBL
    A6ZTT1, B5VI82
    Conserved Domains (1) summary
    pfam00674
    Location:70 → 164
    DUP; DUP family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53053.1

Gene LinkOut

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