ADE57 bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ADE57
Official Full Name: bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase
Primary source: SGD:S000003203
Locus tag: YGL234W
See related: AllianceGenome:SGD:S000003203; FungiDB:YGL234W; VEuPathDB:YGL234W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable phosphoribosylamine-glycine ligase activity and phosphoribosylformylglycinamidine cyclo-ligase activity. Predicted to be involved in adenine biosynthetic process and purine nucleotide biosynthetic process. Located in cytoplasm. Orthologous to human GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ADE57 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (56482..58890)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoribosylamine-glycine ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoribosylamine-glycine ligase activity	IEA Inferred from Electronic Annotation more info
enables phosphoribosylamine-glycine ligase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables phosphoribosylformylglycinamidine cyclo-ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoribosylformylglycinamidine cyclo-ligase activity	IEA Inferred from Electronic Annotation more info
enables phosphoribosylformylglycinamidine cyclo-ligase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in adenine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleobase-containing small molecule metabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleobase metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in purine nucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine-containing compound metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase

NP_011280.1

EC 6.3.3.1

EC 6.3.4.13

Bifunctional enzyme of 'de novo' purine nucleotide pathway; contains both phosphoribosylglycinamidine synthetase/glycinamide ribotide synthetase (EC 6.3.4.13) ['Ade5'] and phosphoribosylaminoimidazole synthetase/aminoimidazole ribotide synthetase (EC 6.3.3.1) ['Ade7'] activities

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

56482..58890

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181100.1 → NP_011280.1 TPA: bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase [Saccharomyces cerevisiae S288C]

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVA0, E9P907, P07244

UniProtKB/TrEMBL

A6ZTV6, B3LHS7, C7GNY1, C8Z821, G2WDM5, N1P3F9

Conserved Domains (2) summary

TIGR00877
Location:2 → 441

purD; phosphoribosylamine--glycine ligase

TIGR00878
Location:450 → 786

purM; phosphoribosylaminoimidazole synthetase