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Cnga1 cyclic nucleotide gated channel subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85259, updated on 2-Nov-2024

Summary

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Official Symbol
Cnga1provided by RGD
Official Full Name
cyclic nucleotide gated channel subunit alpha 1provided by RGD
Primary source
RGD:621815
See related
EnsemblRapid:ENSRNOG00000004778 AllianceGenome:RGD:621815
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
HCN; Cncg
Summary
Enables cGMP binding activity and intracellularly cGMP-activated cation channel activity. Involved in membrane depolarization; regulation of cytosolic calcium ion concentration; and spermatogenesis. Located in terminal bouton. Part of intracellular cyclic nucleotide activated cation channel complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 49. Orthologous to human CNGA1 (cyclic nucleotide gated channel subunit alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 15.9), Thymus (RPKM 3.0) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cnga1 in Genome Data Viewer
Location:
14p11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (35920948..35959065)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (35566947..35605065)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (38155771..38171107)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene TXK tyrosine kinase Neighboring gene NIPA-like domain containing 1 Neighboring gene nuclear transcription factor, X-box binding-like 1 Neighboring gene corin, serine peptidase Neighboring gene acidic leucine-rich nuclear phosphoprotein 32 family member A-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Selective Modulation of Histaminergic Inputs on Projection Neurons of Cerebellum Rapidly Promotes Motor Coordination via HCN Channels. Zhang J, et al. Mol Neurobiol, 2016 Mar. PMID 25633097
  2. Isolation and characterization of the alpha-subunit of the rat rod photoreceptor cGMP-gated cation channel. Barnstable CJ, et al. J Mol Neurosci, 1995. PMID 8860239
  3. Cloning and widespread distribution of the rat rod-type cyclic nucleotide-gated cation channel. Ding C, et al. Am J Physiol, 1997 Apr. PMID 9142860
  4. Expression of subunits for the cAMP-sensitive 'olfactory' cyclic nucleotide-gated ion channel in the cochlea: implications for signal transduction. Drescher MJ, et al. Brain Res Mol Brain Res, 2002 Jan 31. PMID 11834291
  5. Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner. Brewster A, et al. J Neurosci, 2002 Jun 1. PMID 12040066, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interaction Between HCN and Slack Channels Regulates mPFC Pyramidal Cell Excitability in Working Memory Circuits.
    Title: Interaction Between HCN and Slack Channels Regulates mPFC Pyramidal Cell Excitability in Working Memory Circuits.
  2. Histamine depolarizes projection neurons but not interneurons in the cerebellar nuclei via the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels coupled to histamine H2 receptors.
    Title: Selective Modulation of Histaminergic Inputs on Projection Neurons of Cerebellum Rapidly Promotes Motor Coordination via HCN Channels.
  3. Insulin receptor (IR), an integral membrane protein, directly phosphorylates the CNGA1 subunit of CNG channels that in turn affects the function of these channels negatively. CNGA1 is a direct substrate of IR.
    Title: Insulin receptor regulates photoreceptor CNG channel activity.
  4. estrogen and progesterone act in renal tissues modulating CNG-A1 and Na/K ATPase gene expression
    Title: Role of estrogen and progesterone in the modulation of CNG-A1 and Na/K+-ATPase expression in the renal cortex.
  5. Data demonstrate that CNGA1 is expressed in rat cerebellar granule cells and forms functional channels.
    Title: Functional cGMP-gated channels in cerebellar granule cells.
  6. Data show robust CNGA1 (but not CNGA2 or CNGA3) channel expression principally in rat alveolar type I cells and suggest that CNGA1 channels mediate cGMP-stimulated, amiloride-insensitive, lung liquid absorption.
    Title: Alveolar epithelial CNGA1 channels mediate cGMP-stimulated, amiloride-insensitive, lung liquid absorption.
  7. Grb14 is a normal physiological modulator of CNG channel function in vivo.
    Title: Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel.
  8. suggest a potential role for HCN channels in regulation of glucagon secretion via modulating Ca(2+) and Na(+) channel activities
    Title: Presence of functional hyperpolarisation-activated cyclic nucleotide-gated channels in clonal alpha cell lines and rat islet alpha cells.
  9. Our data imply that HCN-expressing GABAergic neurons provide rhythmic drive in all phases of the hippocampal theta activity.
    Title: The presence of pacemaker HCN channels identifies theta rhythmic GABAergic neurons in the medial septum.
  10. Cyclic nucleotide-gated channels (CNG1 and CNG2 A subunits) affect membrane potential and excitability of rat medial vestibular nucleus.
    Title: Functional role of cyclic nucleotide-gated channels in rat medial vestibular nucleus neurons.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cAMP binding IEA
Inferred from Electronic Annotation
more info
  
enables cAMP binding ISO
Inferred from Sequence Orthology
more info
  
enables cAMP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cGMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cGMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cGMP binding IEA
Inferred from Electronic Annotation
more info
  
enables cGMP binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables intracellularly cAMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables intracellularly cAMP-activated cation channel activity IEA
Inferred from Electronic Annotation
more info
  
enables intracellularly cAMP-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables intracellularly cAMP-activated cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables intracellularly cGMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables intracellularly cGMP-activated cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables intracellularly cGMP-activated cation channel activity IEA
Inferred from Electronic Annotation
more info
  
enables intracellularly cGMP-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in membrane depolarization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of intracellular cyclic nucleotide activated cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of intracellular cyclic nucleotide activated cation channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
  
located_in photoreceptor outer segment membrane IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor outer segment membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane bounded cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in rod photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
  
located_in rod photoreceptor outer segment ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cyclic nucleotide-gated channel alpha-1; cGMP-gated cation channel alpha-1
Names
CNG channel alpha-1
CNG-1
CNG1
cyclic nucleotide gated channel alpha 1
cyclic nucleotide-gated cation channel 1
cyclic nucleotide-gated channel, photoreceptor
rod photoreceptor cGMP-gated cation channel subunit alpha
rod photoreceptor cGMP-gated channel subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053497.2 → NP_445949.2  cyclic nucleotide-gated channel alpha-1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    O08659, Q62927
    UniProtKB/TrEMBL
    F1LQN0
    Related
    ENSRNOP00000006469.4, ENSRNOT00000006469.6
    Conserved Domains (3) summary
    cd00038
    Location:470 → 586
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:156 → 398
    Ion_trans; Ion transport protein
    pfam16526
    Location:586 → 655
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    35920948..35959065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092516.2 → XP_038948444.1  cGMP-gated cation channel alpha-1 isoform X1

    UniProtKB/Swiss-Prot
    O08659, Q62927
    UniProtKB/TrEMBL
    F1LQN0
    Conserved Domains (3) summary
    cd00038
    Location:470 → 586
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:156 → 398
    Ion_trans; Ion transport protein
    pfam16526
    Location:586 → 655
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62927.1 GenPept UniProtKB/Swiss-Prot:Q62927

Gene LinkOut

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