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GPX2 glutathione peroxidase GPX2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852546, updated on 2-Nov-2024

Summary

Official Symbol
GPX2
Official Full Name
glutathione peroxidase GPX2
Primary source
SGD:S000000448
Locus tag
YBR244W
See related
AllianceGenome:SGD:S000000448; FungiDB:YBR244W; VEuPathDB:YBR244W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AMI1
Summary
Enables glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. Involved in cellular response to oxidative stress. Located in cytoplasm. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See GPX2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (707528..708016)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene 5'-deoxynucleotidase Neighboring gene UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase Neighboring gene chromatin-remodeling ATPase ISW1 Neighboring gene diphthamide synthase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glutathione peroxidase GPX2
NP_009803.3
  • Phospholipid hydroperoxide glutathione peroxidase; late-acting antioxidant system that decreases mitochondrial ROS production and preserves electron transport chain (ETC) function; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    707528..708016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178592.3NP_009803.3  TPA: glutathione peroxidase GPX2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009803.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQP0, P38143
    UniProtKB/TrEMBL
    A6ZLI3, B3LMR8, C7GMY7, G2W9P7, N1P8J4
    Conserved Domains (1) summary
    COG0386
    Location:1162
    BtuE; Glutathione peroxidase, house-cleaning role in reducing lipid peroxides [Defense mechanisms, Lipid transport and metabolism]