OM14 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: OM14
Primary source: FungiDB:YBR230C
Locus tag: YBR230C
See related: SGD:S000000434; AllianceGenome:SGD:S000000434; VEuPathDB:YBR230C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables nascent polypeptide-associated complex binding activity. Involved in protein targeting to mitochondrion and ribosome localization. Is integral component of mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

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The multi-factor modulated biogenesis of the mitochondrial multi-span protein Om14.
Title: The multi-factor modulated biogenesis of the mitochondrial multi-span protein Om14.
OM14 is a mitochondrial receptor for cytosolic ribosomes that supports co-translational import into mitochondria
Title: OM14 is a mitochondrial receptor for cytosolic ribosomes that supports co-translational import into mitochondria.
Saccharomyces cerevisiae porin pore forms complexes with mitochondrial outer membrane proteins Om14p and Om45p.
Title: Saccharomyces cerevisiae porin pore forms complexes with mitochondrial outer membrane proteins Om14p and Om45p.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables nascent polypeptide-associated complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables nascent polypeptide-associated complex binding	IDA Inferred from Direct Assay more info	PubMed
enables nascent polypeptide-associated complex binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein targeting to mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosome localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner-outer membrane contact site	IPI Inferred from Physical Interaction more info	PubMed
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_009789.1

Mitochondrial outer membrane receptor for cytosolic ribosomes; integral protein of the outer membrane that interacts with the nascent chain-associated complex (NAC) bound to ribosomes, contributing to co-translational mitochondrial import; interacts with porin (Por1p) and Om45p; abundance is decreased in cells grown in glucose relative to other carbon sources