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Gas7 growth arrest specific 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85246, updated on 2-Nov-2024

Summary

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Official Symbol
Gas7provided by RGD
Official Full Name
growth arrest specific 7provided by RGD
Primary source
RGD:621550
See related
EnsemblRapid:ENSRNOG00000049361 AllianceGenome:RGD:621550
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin filament binding activity and identical protein binding activity. Predicted to be involved in actin filament polymerization and neuron projection morphogenesis. Predicted to act upstream of or within actin filament bundle assembly; neuron differentiation; and regulation of cell shape. Predicted to be located in ruffle. Predicted to be active in actin filament; cytoplasm; and plasma membrane. Orthologous to human GAS7 (growth arrest specific 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 251.1), Heart (RPKM 71.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gas7 in Genome Data Viewer
Location:
10q24
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (52651690..52882244)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (52152718..52383283)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (54010723..54240805)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene myosin heavy chain 13 Neighboring gene ATP synthase membrane subunit K, pseudogene 1 Neighboring gene recoverin Neighboring gene glucagon-like peptide 2 receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of rat Gas7 isoforms differentially expressed in brain and regulated following kainate-induced neuronal injury. Chang PY, et al. J Neurosci Res, 2005 Mar 15. PMID 15657892
  2. The gas7 protein potentiates NGF-mediated differentiation of PC12 cells. Lortie K, et al. Brain Res, 2005 Mar 2. PMID 15725398
  3. gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation. Ju YT, et al. Proc Natl Acad Sci U S A, 1998 Sep 15. PMID 9736752, Free PMC Article
  4. Adipose stem cell-derived exosomes promote wound healing by regulating the let-7i-5p/GAS7 axis. Liu X, et al. J Cosmet Dermatol, 2024 Jun. PMID 38429909
  5. Association of the growth-arrest-specific protein Gas7 with F-actin induces reorganization of microfilaments and promotes membrane outgrowth. She BR, et al. Exp Cell Res, 2002 Feb 1. PMID 11795944

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adipose stem cell-derived exosomes promote wound healing by regulating the let-7i-5p/GAS7 axis.
    Title: Adipose stem cell-derived exosomes promote wound healing by regulating the let-7i-5p/GAS7 axis.
  2. Differential expression and unique regulation of Gas7 isoforms in brain subregions may be important in specialized brain functions. Conservation of Gas7 isoforms by alternative splicing in mammals is also considered.
    Title: Identification of rat Gas7 isoforms differentially expressed in brain and regulated following kainate-induced neuronal injury.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin filament ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
growth arrest-specific protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414201.2 → NP_001401130.1  growth arrest-specific protein 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5ZM72
    Related
    ENSRNOP00000079001.1, ENSRNOT00000098305.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    52651690..52882244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086994.2 → XP_038942922.1  growth arrest-specific protein 7 isoform X5

    Conserved Domains (2) summary
    cd07649
    Location:91 → 323
    F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
    pfam16623
    Location:33 → 78
    WW_FCH_linker; Unstructured linker region between on GAS7 protein

  2. XM_039086991.2 → XP_038942919.1  growth arrest-specific protein 7 isoform X1

    Conserved Domains (2) summary
    cd07649
    Location:211 → 443
    F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
    pfam16623
    Location:153 → 198
    WW_FCH_linker; Unstructured linker region between on GAS7 protein

  3. XM_006246828.5 → XP_006246890.1  growth arrest-specific protein 7 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A9M5, M0RD55
    Related
    ENSRNOP00000088350.1, ENSRNOT00000100512.2
    Conserved Domains (2) summary
    cd07649
    Location:161 → 393
    F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
    pfam16623
    Location:67 → 148
    WW_FCH_linker; Unstructured linker region between on GAS7 protein

  4. XM_039086995.2 → XP_038942923.1  growth arrest-specific protein 7 isoform X5

    Conserved Domains (2) summary
    cd07649
    Location:91 → 323
    F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
    pfam16623
    Location:33 → 78
    WW_FCH_linker; Unstructured linker region between on GAS7 protein

  5. XM_006246829.5 → XP_006246891.1  growth arrest-specific protein 7 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AJ10, M0RD55
    Related
    ENSRNOP00000104800.1, ENSRNOT00000126123.1
    Conserved Domains (2) summary
    cd07649
    Location:154 → 386
    F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
    pfam16623
    Location:60 → 141
    WW_FCH_linker; Unstructured linker region between on GAS7 protein

  6. XM_006246830.5 → XP_006246892.1  growth arrest-specific protein 7 isoform X4

    See identical proteins and their annotated locations for XP_006246892.1

    UniProtKB/TrEMBL
    A6HFI8, M0RD55
    Related
    ENSRNOP00000067551.2, ENSRNOT00000072855.4
    Conserved Domains (2) summary
    cd07649
    Location:150 → 382
    F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
    pfam16623
    Location:56 → 137
    WW_FCH_linker; Unstructured linker region between on GAS7 protein

  7. XM_039086992.2 → XP_038942920.1  growth arrest-specific protein 7 isoform X5

    Conserved Domains (2) summary
    cd07649
    Location:91 → 323
    F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
    pfam16623
    Location:33 → 78
    WW_FCH_linker; Unstructured linker region between on GAS7 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O55148.2 GenPept UniProtKB/Swiss-Prot:O55148

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