Plcb2 phospholipase C, beta 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plcb2provided by RGD
Official Full Name: phospholipase C, beta 2provided by RGD
Primary source: RGD:621004
See related: EnsemblRapid:ENSRNOG00000058337 AllianceGenome:RGD:621004
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables G-protein beta/gamma-subunit complex binding activity; phosphatidylinositol phospholipase C activity; and phospholipid binding activity. Involved in detection of chemical stimulus involved in sensory perception of bitter taste and phospholipase C-activating G protein-coupled receptor signaling pathway. Part of G-protein beta/gamma-subunit complex. Orthologous to human PLCB2 (phospholipase C beta 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Spleen (RPKM 78.5), Lung (RPKM 46.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (126134925..126158303, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (105683676..105704384, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (110497760..110517563, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PKC-betaII is downregulated in the premature ovarian failure SD rat model.
Title: PKC-βII is downregulated in the premature ovarian failure SD rat model.
levels of Galphaq, Galpha11, PLCbeta-1, and PLC-beta2 proteins, as determined by western blotting, are significantly higher in vascular smooth muscle cells exposed to high glucose than in control cells.
Title: Role of vasoactive peptides in high glucose-induced increased expression of Gαq/11 proteins and associated signaling in vascular smooth muscle cells.
High glucose increases the expression of Gq/11alpha and PLC-beta proteins and associated signaling in vascular smooth muscle cells.
Title: High glucose increases the expression of Gq/11alpha and PLC-beta proteins and associated signaling in vascular smooth muscle cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Plcb2 (e-PCR), detects polymorphism
- UniSTS:532519

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-protein beta/gamma-subunit complex binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol phospholipase C activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol phospholipase C activity	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipase C activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of bitter taste	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of bitter taste	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of G-protein beta/gamma-subunit complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in neuronal dense core vesicle	IEA Inferred from Electronic Annotation more info
is_active_in neuronal dense core vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Names: PKC beta II; PLC-beta-2; phosphoinositide phospholipase C-beta-2

NP_445930.1

EC 3.1.4.11

XP_038961925.1

EC 3.1.4.11

XP_063140803.1

EC 3.1.4.11

XP_063140804.1

EC 3.1.4.11

XP_063140805.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053478.2 → NP_445930.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

See identical proteins and their annotated locations for NP_445930.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

O89040

UniProtKB/TrEMBL

A0A0G2JZ43

Related

ENSRNOP00000070903.3, ENSRNOT00000078037.3

Conserved Domains (8) summary

cd00275
Location:685 → 806

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08624
Location:311 → 653

PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2

PLN02222
Location:219 → 804

PLN02222; phosphoinositide phospholipase C 2

COG4942
Location:827 → 1072

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd13361
Location:17 → 144

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

pfam08703
Location:976 → 1151

PLC-beta_C; PLC-beta C terminal

pfam09279
Location:220 → 311

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

cl11531
Location:1040 → 1119

DUF904; Protein of unknown function (DUF904)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

126134925..126158303 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284733.1 → XP_063140803.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
XM_063284734.1 → XP_063140804.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2
XM_063284735.1 → XP_063140805.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3
XM_039105997.1 → XP_038961925.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4

Conserved Domains (3) summary

cd16209
Location:149 → 299

EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)

pfam17787
Location:12 → 141

PH_14; PH domain

cl14615
Location:311 → 441

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily