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HTA2 histone H2A [ Saccharomyces cerevisiae S288C ]

Gene ID: 852283, updated on 3-Nov-2024

Summary

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Official Symbol
HTA2
Official Full Name
histone H2A
Primary source
SGD:S000000099
Locus tag
YBL003C
See related
AllianceGenome:SGD:S000000099; FungiDB:YBL003C; VEuPathDB:YBL003C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
H2A2
Summary
Predicted to be a structural constituent of chromatin. Involved in DNA repair. Part of replication fork protection complex. Orthologous to several human genes including H2AC1 (H2A clustered histone 1); H2AC14 (H2A clustered histone 14); and H2AC15 (H2A clustered histone 15). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See HTA2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (235394..235792, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene Utp20p Neighboring gene histone H2B Neighboring gene Ecm15p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved sequence in histone H2A which is a ubiquitination site in higher eucaryotes is not required for growth in Saccharomyces cerevisiae. Swerdlow PS, et al. Mol Cell Biol, 1990 Sep. PMID 2201907, Free PMC Article
  2. Either of the major H2A genes but not an evolutionarily conserved H2A.F/Z variant of Tetrahymena thermophila can function as the sole H2A gene in the yeast Saccharomyces cerevisiae. Liu X, et al. Mol Cell Biol, 1996 Jun. PMID 8649398, Free PMC Article
  3. Chromatin stiffening underlies enhanced locus mobility after DNA damage in budding yeast. Herbert S, et al. EMBO J, 2017 Sep 1. PMID 28694242, Free PMC Article
  4. Functional analysis of histones H2A and H2B in transcriptional repression in Saccharomyces cerevisiae. Recht J, et al. Mol Cell Biol, 1996 Jun. PMID 8649361, Free PMC Article
  5. The effect of histone gene deletions on chromatin structure in Saccharomyces cerevisiae. Norris D, et al. Science, 1988 Nov 4. PMID 2847314

See all (249) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. H2A.1 promotes high-fidelity homologous recombination, sister chromatid recombination (SCR), and break-induced replication whereas H2A.2 does not share these functions. Both decreased SCR and the increase in CAG expansions were due to the unique Thr126 residue in H2A.1 and hta1Delta or hta1-T126A mutants were epistatic to deletion of the Poldelta subunit Pol32, suggesting a role for H2A.1 in D-loop extension.
    Title: Distinct roles for S. cerevisiae H2A copies in recombination and repeat stability, with a role for H2A.1 threonine 126.
  2. The data identifies novel roles of the histone H2A N-tail in (i) regulating the expression of a critical BER enzyme (Mag1), (ii) supporting efficient DNA damage signaling and (iii) facilitating postreplication repair.
    Title: The amino-terminal tails of histones H2A and H3 coordinate efficient base excision repair, DNA damage signaling and postreplication repair in Saccharomyces cerevisiae.
  3. H2A phosphorylation promotes two independent events, rapid Rad9 recruitment to DSBs and subsequent remodeling by NuA4, SWR, and INO80.
    Title: Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of nucleosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
part_of nucleosome TAS
Traceable Author Statement
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of replication fork protection complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone H2A
NP_009552.1
  • Histone H2A; core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    235394..235792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178243.1 → NP_009552.1  TPA: histone H2A [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009552.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPZ9, P04912
    UniProtKB/TrEMBL
    A6ZKU5, B3LNE2, C7GM51, C8Z3Z5, G2W906, N1P913
    Conserved Domains (1) summary
    PTZ00017
    Location:18 → 131
    PTZ00017; histone H2A; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04912.2

Gene LinkOut

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