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RIB1 GTP cyclohydrolase II [ Saccharomyces cerevisiae S288C ]

Gene ID: 852247, updated on 28-Oct-2024

Summary

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Official Symbol
RIB1
Official Full Name
GTP cyclohydrolase II
Primary source
SGD:S000000129
Locus tag
YBL033C
See related
AllianceGenome:SGD:S000000129; FungiDB:YBL033C; VEuPathDB:YBL033C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cyclohydrolase activity. Involved in riboflavin biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See RIB1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (158656..159693, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene DNA-directed DNA polymerase alpha subunit POL12 Neighboring gene Stu1p Neighboring gene Hek2p Neighboring gene She1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Novel Mechanism for Nitrosative Stress Tolerance Dependent on GTP Cyclohydrolase II Activity Involved in Riboflavin Synthesis of Yeast. Anam K, et al. Sci Rep, 2020 Apr 7. PMID 32265460, Free PMC Article
  2. Mapping of the RIB1 and RIB7 genes involved in the biosynthesis of riboflavin in Saccharomyces cerevisiae. Buitrago MJ, et al. Yeast, 1993 Oct. PMID 8256517
  3. Biosynthesis of riboflavine in Saccharomyces cerevisiae: the role of genes rib 1 and rib 7 . Oltmanns O, et al. J Bacteriol, 1972 Jun. PMID 4555411, Free PMC Article
  4. Biosynthesis of riboflavin: characterization of the bifunctional deaminase-reductase of Escherichia coli and Bacillus subtilis. Richter G, et al. J Bacteriol, 1997 Mar. PMID 9068650, Free PMC Article
  5. Genetical classification of riboflavineless mutants of Saccharomyces cerevisiae. Oltmanns O, et al. Antonie Van Leeuwenhoek, 1969 Jun. PMID 5312045

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Novel Mechanism for Nitrosative Stress Tolerance Dependent on GTP Cyclohydrolase II Activity Involved in Riboflavin Synthesis of Yeast.
    Title: A Novel Mechanism for Nitrosative Stress Tolerance Dependent on GTP Cyclohydrolase II Activity Involved in Riboflavin Synthesis of Yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP cyclohydrolase II activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclohydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in riboflavin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in riboflavin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in riboflavin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
GTP cyclohydrolase II
NP_009520.1
  • GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    158656..159693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178273.1 → NP_009520.1  TPA: GTP cyclohydrolase II [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009520.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPW6, P38066
    UniProtKB/TrEMBL
    A6ZKR4, B3LNH1, B5VDV0, C7GNC9, C8Z3W3, G2W8X5, N1P9Q7
    Conserved Domains (1) summary
    TIGR00505
    Location:85 → 309
    ribA; GTP cyclohydrolase II
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38066.2

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