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URA7 CTP synthase URA7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852241, updated on 14-Nov-2024

Summary

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Official Symbol
URA7
Official Full Name
CTP synthase URA7
Primary source
SGD:S000000135
Locus tag
YBL039C
See related
AllianceGenome:SGD:S000000135; FungiDB:YBL039C; VEuPathDB:YBL039C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables CTP synthase activity. Involved in CTP biosynthetic process; phospholipid biosynthetic process; and pyrimidine nucleobase biosynthetic process. Located in cytoophidium. Human ortholog(s) of this gene implicated in immunodeficiency 24. Orthologous to human CTPS1 (CTP synthase 1) and CTPS2 (CTP synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See URA7 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (143989..145728, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Erd2p Neighboring gene Min6p Neighboring gene mitochondrial 54S ribosomal protein YmL47 Neighboring gene Apl3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning, sequencing and characterization of the Saccharomyces cerevisiae URA7 gene encoding CTP synthetase. Ozier-Kalogeropoulos O, et al. Mol Gen Genet, 1991 Dec. PMID 1753946
  2. Characterization of a novel dUTP-dependent activity of CTP synthetase from Saccharomyces cerevisiae. Pappas A, et al. Biochemistry, 1999 Dec 14. PMID 10600130
  3. Identification of Ser424 as the protein kinase A phosphorylation site in CTP synthetase from Saccharomyces cerevisiae. Park TS, et al. Biochemistry, 1999 Jul 6. PMID 10393561
  4. Common regulatory control of CTP synthase enzyme activity and filament formation. Noree C, et al. Mol Biol Cell, 2014 Aug 1. PMID 24920825, Free PMC Article
  5. Nucleotide-dependent tetramerization of CTP synthetase from Saccharomyces cerevisiae. Pappas A, et al. J Biol Chem, 1998 Jun 26. PMID 9632643

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Performed a genome-wide screen in Saccharomyces cerevisiae to identify genes linked to high-fidelity DNA replication. Found URA7 or GLN3 inactivation had a role in imbalanced dNTP pools and increased mutagenesis.
    Title: Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis.
  2. The regulatory sites that control CTP synthase function, but not enzymatic activity per se, are critical for controlling filament assembly.
    Title: Common regulatory control of CTP synthase enzyme activity and filament formation.
  3. URA7 has a role in ethanol tolerance.
    Title: Disruption of URA7 and GAL6 improves the ethanol tolerance and fermentation capacity of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CTP synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CTP synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables CTP synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables CTP synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in CTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CTP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyrimidine nucleobase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoophidium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoophidium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole HDA PubMed 

General protein information

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Preferred Names
CTP synthase URA7
NP_009514.1
  • Major CTP synthase isozyme (see also URA8); catalyzes ATP-dependent transfer of amide nitrogen from glutamine to UTP, forming CTP, final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; targeted to vacuole via AP-3 pathway; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has paralog URA8 that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    143989..145728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178279.1 → NP_009514.1  TPA: CTP synthase URA7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009514.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPW0, P28274
    UniProtKB/TrEMBL
    A6ZKQ8, B3LNH7, C7GNC4, C8Z3Q9, G2W8W9, N1P8Z5
    Conserved Domains (1) summary
    TIGR00337
    Location:1 → 555
    PyrG; CTP synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28274.2

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