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YEL1 Arf family guanine nucleotide exchange factor YEL1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852219, updated on 18-Sep-2024

Summary

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Official Symbol
YEL1
Official Full Name
Arf family guanine nucleotide exchange factor YEL1
Primary source
SGD:S000000156
Locus tag
YBL060W
See related
AllianceGenome:SGD:S000000156; FungiDB:YBL060W; VEuPathDB:YBL060W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in actin cortical patch localization; positive regulation of phosphatidylinositol biosynthetic process; and protein localization. Located in cellular bud neck and cellular bud tip. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YEL1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (107932..109995)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Kip1p Neighboring gene Skt5p Neighboring gene Cmc2p Neighboring gene Iai11p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Afi1p functions as an Arf3p polarization-specific docking factor for development of polarity. Tsai PC, et al. J Biol Chem, 2008 Jun 13. PMID 18397879
  2. Identification of a guanine nucleotide exchange factor for Arf3, the yeast orthologue of mammalian Arf6. Gillingham AK, et al. PLoS One, 2007 Sep 5. PMID 17786213, Free PMC Article
  3. Arf3p GTPase is a key regulator of Bud2p activation for invasive growth in Saccharomyces cerevisiae. Hsu JW, et al. Mol Biol Cell, 2013 Aug. PMID 23783029, Free PMC Article
  4. Snf1/AMP-activated protein kinase activates Arf3p to promote invasive yeast growth via a non-canonical GEF domain. Hsu JW, et al. Nat Commun, 2015 Jul 22. PMID 26198097, Free PMC Article
  5. Yeast Arf3p modulates plasma membrane PtdIns(4,5)P2 levels to facilitate endocytosis. Smaczynska-de Rooij II, et al. Traffic, 2008 Apr. PMID 18208507, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cortical patch localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Arf family guanine nucleotide exchange factor YEL1
NP_009493.1
  • Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    107932..109995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178300.1 → NP_009493.1  TPA: Arf family guanine nucleotide exchange factor YEL1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009493.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZKN8, C8Z3N7, D6VPT9, P34225
    UniProtKB/TrEMBL
    G2W8U8
    Conserved Domains (1) summary
    COG5307
    Location:1 → 687
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34225.1

Gene LinkOut

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