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VPS60 Vps60p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852097, updated on 28-Oct-2024

Summary

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Official Symbol
VPS60
Official Full Name
Vps60p
Primary source
SGD:S000002894
Locus tag
YDR486C
See related
AllianceGenome:SGD:S000002894; FungiDB:YDR486C; VEuPathDB:YDR486C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CHM5; MOS10
Summary
Involved in late endosome to vacuole transport via multivesicular body sorting pathway. Located in fungal-type vacuole membrane. Orthologous to human CHMP5 (charged multivesicular body protein 5). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See VPS60 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1427431..1428120, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Vps52p Neighboring gene Vps72p Neighboring gene 3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3 Neighboring gene dynein intermediate chain

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mos10 (Vps60) is required for normal filament maturation in Saccharomyces cerevisiae. Köhler JR. Mol Microbiol, 2003 Sep. PMID 12940986
  2. Characterization of Vta1p, a class E Vps protein in Saccharomyces cerevisiae. Shiflett SL, et al. J Biol Chem, 2004 Mar 19. PMID 14701806
  3. Structural basis of molecular recognition between ESCRT-III-like protein Vps60 and AAA-ATPase regulator Vta1 in the multivesicular body pathway. Yang Z, et al. J Biol Chem, 2012 Dec 21. PMID 23105107, Free PMC Article
  4. Structural basis of Vta1 function in the multivesicular body sorting pathway. Xiao J, et al. Dev Cell, 2008 Jan. PMID 18194651, Free PMC Article
  5. Interactions of ubiquitin and CHMP5 with the V domain of HD-PTP reveals role for regulation of Vps4 ATPase. Pashkova N, et al. Mol Biol Cell, 2021 Dec 1. PMID 34586919, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural basis of molecular recognition between ESCRT-III-like protein Vps60 and AAA-ATPase regulator Vta1 in the multivesicular body pathway.
    Title: Structural basis of molecular recognition between ESCRT-III-like protein Vps60 and AAA-ATPase regulator Vta1 in the multivesicular body pathway.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle budding from membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole membrane HDA PubMed 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vps60p
NP_010774.4
  • Protein involved in late endosome to vacuole transport; cytoplasmic and vacuolar membrane protein; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1427431..1428120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180794.3 → NP_010774.4  TPA: Vps60p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010774.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTA9, Q03390
    UniProtKB/TrEMBL
    A6ZZ75, B3LFI0, B5VH14, C7GKS4, C8Z644, G2WBL5, N1PAL1
    Conserved Domains (1) summary
    pfam03357
    Location:19 → 181
    Snf7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03390.2

Gene LinkOut

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