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MFA1 mating pheromone a [ Saccharomyces cerevisiae S288C ]

Gene ID: 852072, updated on 2-Nov-2024

Summary

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Official Symbol
MFA1
Official Full Name
mating pheromone a
Primary source
SGD:S000002869
Locus tag
YDR461W
See related
AllianceGenome:SGD:S000002869; FungiDB:YDR461W; VEuPathDB:YDR461W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mating pheromone activity. Involved in pheromone-dependent signal transduction involved in conjugation with cellular fusion. Located in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MFA1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1385176..1385286)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene palmitoyltransferase PFA5 Neighboring gene TFIIH/NER complex subunit TFB3 Neighboring gene Cmi8p Neighboring gene mitochondrial 54S ribosomal protein YmL28

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An amino terminal prosequence is required for efficient synthesis of S. cerevisiae a-factor. Quinby GE, et al. Biochim Biophys Acta, 1997 Mar 27. PMID 9099988
  2. Synthesis and farnesylation of a-factor fusion proteins in Saccharomyces cerevisiae. Kölling R, et al. FEBS Lett, 1993 Dec 20. PMID 8262194
  3. Purification and amino acid sequence of mating factor from Saccharomyces cerevisiae. Tanaka T, et al. J Biochem, 1977 Dec. PMID 340452
  4. Structure, biological activity and membrane partitioning of analogs of the isoprenylated a-factor mating peptide of Saccharomyces cerevisiae. Xie H, et al. J Pept Res, 2000 May. PMID 10863934
  5. Facile synthesis of budding yeast a-factor and its use to synchronize cells of α mating type. O'Reilly N, et al. Yeast, 2012 Jun. PMID 22641466

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate the substrate specificity of kexin protein(Kex2)using peptides derived from alpha-mating factor.
    Title: Specificity characterization of the α-mating factor hormone by Kex2 protease.
  2. The loss of viability observed in telomerase-deficient haploids and diploids is less severe when both MATa and MATalpha are co-expressed than when a single MAT allele is expressed.
    Title: Mating type influences chromosome loss and replicative senescence in telomerase-deficient budding yeast by Dnl4-dependent telomere fusion.
  3. Amino acid residues critical for N-terminal processing, protein secretion, and mating were identified from a collection of a-factor mutants.
    Title: Saccharomyces cerevisiae a-factor mutants reveal residues critical for processing, activity, and export.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables mating pheromone activity IEA
Inferred from Electronic Annotation
more info
  
enables mating pheromone activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pheromone activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mating pheromone a
NP_010749.3
  • Mating pheromone a-factor; made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1385176..1385286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180769.3 → NP_010749.3  TPA: mating pheromone a [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010749.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT85, P34165
    UniProtKB/TrEMBL
    A6ZZ51, B3LFK4, C7GKQ2, C8Z619, G2WBJ1, N1P5P2
    Conserved Domains (1) summary
    pfam17317
    Location:1 → 36
    MFA1_2; Mating hormone A-factor 1_2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34165.1

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