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HAT1 histone acetyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 8520, updated on 5-Mar-2024

Summary

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Official Symbol
HAT1provided by HGNC
Official Full Name
histone acetyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:4821
See related
Ensembl:ENSG00000128708 MIM:603053; AllianceGenome:HGNC:4821
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAT1
Summary
The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]
Expression
Ubiquitous expression in lymph node (RPKM 13.0), bone marrow (RPKM 11.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See HAT1 in Genome Data Viewer
Location:
2q31.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (171922461..171983686)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (172400272..172469906)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (172778971..172848600)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373739 Neighboring gene uncharacterized LOC105373740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:172778407-172779055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16760 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:172791325-172791562 Neighboring gene VISTA enhancer hs646 Neighboring gene PDGFA associated protein 1 pseudogene Neighboring gene uncharacterized LOC124905590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12106 Neighboring gene methionyl aminopeptidase type 1D, mitochondrial Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16761 Neighboring gene VISTA enhancer hs553 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:172945060-172945588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:172945589-172946118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:172948655-172949268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:172949269-172949880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:172949881-172950494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:172950495-172951106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:172951721-172952332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:172952946-172953557 Neighboring gene distal-less homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Understanding HAT1: A Comprehensive Review of Noncanonical Roles and Connection with Disease. Ortega MA, et al. Genes (Basel), 2023 Apr 14. PMID 37107673, Free PMC Article
  2. HAT1: Landscape of Biological Function and Role in Cancer. Capone V, et al. Cells, 2023 Apr 2. PMID 37048148, Free PMC Article
  3. Histone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis. Yang G, et al. EMBO Rep, 2021 Feb 3. PMID 33372411, Free PMC Article
  4. HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding. Gruber JJ, et al. Mol Cell, 2019 Aug 22. PMID 31278053, Free PMC Article
  5. Histone acetyltransferase 1 up regulates Bcl2L12 expression in nasopharyngeal cancer cells. Miao BP, et al. Arch Biochem Biophys, 2018 May 15. PMID 29621521

See all (140) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HMGB1/SET/HAT1 complex-mediated SASH1 repression drives glycolysis and metastasis in lung adenocarcinoma.
    Title: HMGB1/SET/HAT1 complex-mediated SASH1 repression drives glycolysis and metastasis in lung adenocarcinoma.
  2. Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging.
    Title: Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging.
  3. Understanding HAT1: A Comprehensive Review of Noncanonical Roles and Connection with Disease.
    Title: Understanding HAT1: A Comprehensive Review of Noncanonical Roles and Connection with Disease.
  4. HAT1: Landscape of Biological Function and Role in Cancer.
    Title: HAT1: Landscape of Biological Function and Role in Cancer.
  5. FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer.
    Title: FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer.
  6. Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1/EZH2 complex in pancreatic cancer.
    Title: Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1/EZH2 complex in pancreatic cancer.
  7. Proteomic analysis identifies novel binding partners of BAP1.
    Title: Proteomic analysis identifies novel binding partners of BAP1.
  8. Histone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis.
    Title: Histone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis.
  9. these data describe a feedforward circuit whereby HAT1 captures acetyl groups on nascent histones and drives H4 production by chromatin binding to support chromatin replication and acetylation.
    Title: HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding.
  10. High HAT1 expression is associated with Pancreatic ductal adenocarcinoma.
    Title: Overexpressed histone acetyltransferase 1 regulates cancer immunity by increasing programmed death-ligand 1 expression in pancreatic cancer.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120 PubMed
Vpr vpr HIV-1 Vpr forms a complex by recruiting RbAp46, HAT1, ZIP/sZIP, and Cul4A PubMed
vpr HIV-1 Vpr is identified to have a physical interaction with histone acetyltransferase 1 (HAT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone H4 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H4K12 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables histone binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromosome organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in internal protein amino acid acetylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in subtelomeric heterochromatin formation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, telomeric region HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone acetyltransferase type B catalytic subunit
NP_003633.2
XP_006712871.1
XP_054188848.1
XP_054200225.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003642.4 → NP_003633.2  histone acetyltransferase type B catalytic subunit

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AC114745
    Consensus CDS
    CCDS2245.1
    UniProtKB/Swiss-Prot
    O14929, Q49A44, Q53QF0, Q53SU4, Q6P594, Q8WWB9
    Related
    ENSP00000264108.4, ENST00000264108.5
    Conserved Domains (1) summary
    pfam10394
    Location:25 → 187
    Hat1_N; Histone acetyl transferase HAT1 N-terminus

RNA

  1. NR_027862.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC114745
    Related
    ENST00000412731.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    171922461..171983686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712808.4 → XP_006712871.1  histone acetyltransferase type B catalytic subunit isoform X1

    See identical proteins and their annotated locations for XP_006712871.1

    Conserved Domains (1) summary
    pfam10394
    Location:19 → 181
    Hat1_N; Histone acetyl transferase HAT1 N-terminus

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791761.1 Reference GRCh38.p14 PATCHES

    Range
    353079..422730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332873.1 → XP_054188848.1  histone acetyltransferase type B catalytic subunit isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    172400272..172469906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344250.1 → XP_054200225.1  histone acetyltransferase type B catalytic subunit isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033085.1: Suppressed sequence

    Description
    NM_001033085.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14929.2 GenPept UniProtKB/Swiss-Prot:O14929

Gene LinkOut

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