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SRB7 Srb7p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851903, updated on 29-Jun-2024

Summary

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Gene symbol
SRB7
Gene description
Srb7p
Primary source
FungiDB:YDR308C
Locus tag
YDR308C
See related
SGD:S000002716; AllianceGenome:SGD:S000002716; VEuPathDB:YDR308C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MED21; SSX1
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Part of core mediator complex and mediator complex. Orthologous to human MED21 (mediator complex subunit 21). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SRB7 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1078027..1078449, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA-Val Neighboring gene putative dolichyl-phosphate-mannose--protein mannosyltransferase Neighboring gene Gic2p Neighboring gene Sum1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Srb7p is essential for the activation of a subset of genes. Gromöller A, et al. FEBS Lett, 2000 Oct 27. PMID 11056220
  2. An RNA polymerase II holoenzyme responsive to activators. Koleske AJ, et al. Nature, 1994 Mar 31. PMID 8133894
  3. Srb7p is a physical and physiological target of Tup1p. Gromöller A, et al. EMBO J, 2000 Dec 15. PMID 11118219, Free PMC Article
  4. General requirement for RNA polymerase II holoenzymes in vivo. Thompson CM, et al. Proc Natl Acad Sci U S A, 1995 May 9. PMID 7753848, Free PMC Article
  5. Cell cycle-specific expression of the SWI4 transcription factor is required for the cell cycle regulation of HO transcription. Breeden L, et al. Genes Dev, 1991 Jul. PMID 2065973

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription corepressor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of core mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Srb7p
NP_010594.3
  • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1078027..1078449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180616.3 → NP_010594.3  TPA: Srb7p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010594.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VST7, P47822
    UniProtKB/TrEMBL
    A0A6A5Q418, A6ZYQ6, B3LFY8, C7GQV8, C8Z5L9, G2WB46, N1PAH5
    Conserved Domains (1) summary
    pfam11221
    Location:1 → 131
    Med21; Subunit 21 of Mediator complex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47822.1

Gene LinkOut

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