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IFITM1 interferon induced transmembrane protein 1 [ Homo sapiens (human) ]

Gene ID: 8519, updated on 7-Apr-2024

Summary

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Official Symbol
IFITM1provided by HGNC
Official Full Name
interferon induced transmembrane protein 1provided by HGNC
Primary source
HGNC:HGNC:5412
See related
Ensembl:ENSG00000185885 MIM:604456; AllianceGenome:HGNC:5412
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
9-27; CD225; IFI17; LEU13; DSPA2a
Summary
Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 that belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in spleen (RPKM 191.9), endometrium (RPKM 153.8) and 24 other tissues See more
Orthologs
all
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Genomic context

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See IFITM1 in Genome Data Viewer
Location:
11p15.5
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (314040..315272)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (355743..359591, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (314040..315272)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:305823-306334 Neighboring gene mitochondrial ribosomal protein S24 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:311550-312155 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:313425-313980 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:313981-314536 Neighboring gene interferon induced transmembrane protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4265 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2994 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4266 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:316761-317316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4267 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:318431-318986 Neighboring gene uncharacterized LOC105376505 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:318987-319542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:320655-321210 Neighboring gene interferon induced transmembrane protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4268 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4271 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:333329-333882 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:333883-334436 Neighboring gene CRISPRi-validated cis-regulatory element chr11.30 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4272 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:353490-353656 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:354319-354895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:355877-356829 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:368032-368570 Neighboring gene beta-1,4-N-acetyl-galactosaminyltransferase 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:380111-380268

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. IFITM1 expression determines extracellular vesicle uptake in colorectal cancer. Kelemen A, et al. Cell Mol Life Sci, 2021 Nov. PMID 34609520, Free PMC Article
  2. Disrupting interferon-alpha and NF-kappaB crosstalk suppresses IFITM1 expression attenuating triple-negative breast cancer progression. Provance OK, et al. Cancer Lett, 2021 Aug 28. PMID 34022283, Free PMC Article
  3. Expression of IFN-induced transmembrane protein 1 in glomerular endothelial cells. Hashimoto S, et al. Pediatr Int, 2021 Sep. PMID 33332692
  4. Interferon-induced transmembrane protein 1 (IFITM1) is essential for progression of laryngeal squamous cell carcinoma in an Osteopontin/NF-κB-dependent manner. Yin Y, et al. Cancer Biomark, 2020. PMID 32865181
  5. Interferon-Induced Transmembrane Protein 1 (IFITM1) Promotes Distant Metastasis of Small Cell Lung Cancer. Sakamoto S, et al. Int J Mol Sci, 2020 Jul 13. PMID 32668617, Free PMC Article

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IFITM1 and IFITM3 Proteins Inhibit the Infectivity of Progeny HIV-1 without Disrupting Envelope Glycoprotein Clusters.
    Title: IFITM1 and IFITM3 Proteins Inhibit the Infectivity of Progeny HIV-1 without Disrupting Envelope Glycoprotein Clusters.
  2. Genome-wide DNA methylation analysis implicates enrichment of interferon pathway in African American patients with Systemic Lupus Erythematosus and European Americans with lupus nephritis.
    Title: Genome-wide DNA methylation analysis implicates enrichment of interferon pathway in African American patients with Systemic Lupus Erythematosus and European Americans with lupus nephritis.
  3. Toll-like receptor 3 signaling induces interferon-induced transmembrane protein 1 in BEAS-2B cells.
    Title: Toll-like receptor 3 signaling induces interferon-induced transmembrane protein 1 in BEAS-2B cells.
  4. Co-expression of DDR2 and IFITM1 promotes breast cancer cell proliferation, migration and invasion and inhibits apoptosis.
    Title: Co-expression of DDR2 and IFITM1 promotes breast cancer cell proliferation, migration and invasion and inhibits apoptosis.
  5. MiR-504-3p Has Tumor-Suppressing Activity and Decreases IFITM1 Expression in Non-Small Cell Lung Cancer Cells.
    Title: MiR-504-3p Has Tumor-Suppressing Activity and Decreases IFITM1 Expression in Non-Small Cell Lung Cancer Cells.
  6. Emergent Role of IFITM1/3 towards Splicing Factor (SRSF1) and Antigen-Presenting Molecule (HLA-B) in Cervical Cancer.
    Title: Emergent Role of IFITM1/3 towards Splicing Factor (SRSF1) and Antigen-Presenting Molecule (HLA-B) in Cervical Cancer.
  7. Differential Leukocyte Expression of IFITM1 and IFITM3 in Patients with Severe Pandemic Influenza A(H1N1) and COVID-19.
    Title: Differential Leukocyte Expression of IFITM1 and IFITM3 in Patients with Severe Pandemic Influenza A(H1N1) and COVID-19.
  8. Interferon-Induced Transmembrane Proteins Inhibit Infection by the Kaposi's Sarcoma-Associated Herpesvirus and the Related Rhesus Monkey Rhadinovirus in a Cell-Specific Manner.
    Title: Interferon-Induced Transmembrane Proteins Inhibit Infection by the Kaposi's Sarcoma-Associated Herpesvirus and the Related Rhesus Monkey Rhadinovirus in a Cell-Specific Manner.
  9. Disrupting interferon-alpha and NF-kappaB crosstalk suppresses IFITM1 expression attenuating triple-negative breast cancer progression.
    Title: Disrupting interferon-alpha and NF-kappaB crosstalk suppresses IFITM1 expression attenuating triple-negative breast cancer progression.
  10. IFITM1 expression determines extracellular vesicle uptake in colorectal cancer.
    Title: IFITM1 expression determines extracellular vesicle uptake in colorectal cancer.
Submit: New GeneRIF Correction See all GeneRIFs (80)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 incorporates IFITM1 into virions but this incorporation does not strictly correlate with the phenotype of IFITM inhibition of HIV-1 cell-to-cell infection PubMed
Knockdown of IFITM1/2/3 by siRNA enhances virus transmission to target cells and the production of virions in CD4+ T cells PubMed
HIV-1 cell-to-cell transmission (Jurkat-to-Jurkat and PBMCs-to-Jurkat) is inhibited by IFITM1 PubMed
HIV-1 cell-to-cell transmission (Jurkat-to-Jurkat) is inhibited by IFITM1 and this inhibition appears to be regulated by the IFITM protein C terminus, is IFITM-species specific and virus-strain specific PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 interacts with IFITM1 PubMed
Envelope surface glycoprotein gp160, precursor env Replacement of the Env of HIV-1 BH10 with the counterpart of HIV-1 NL4-3 enables HIV-1 BH10 to replicate in IFITM1-expressing cells, whereas inserting the Env of HIV-1 BH10 into HIV-1 NL4-3 reduces virus replication in the presence of IFITM1 PubMed
env HIV-1 NL4-3 Env inhibits IFITM1-mediated restriction of HIV-1 replication by enhancing HIV-1 cell-to-cell transmission PubMed
env Vpu34 (a stop-codon at position 35) and EnvG367E mutations rescue HIV-1 replication in IFITM1-expressing SupT1 cells by enhancing HIV-1 cell-to-cell transmission PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 interacts with IFITM1 PubMed
Nef nef IFITM1 significantly downregulates the expression of HIV-1 Nef by interfering with Tat/TAR-mediated expression PubMed
Pr55(Gag) gag IFITM1, IFITM2, and IFITM3 proteins (IFITMs) co-localize with HIV-1 Gag in virus-producing cells and co-assemble with Gag into budding particles PubMed
gag Endogenous IFITM1/2/3 proteins are upregulated in activated CD4+ T cells and incorporated into HIV-1 Gag/p24-associated virions during infection PubMed
gag IFITM1 significantly downregulates the expression of HIV-1 Gag and CA by interfering with both Rev/RRE- and Tat/TAR-mediated expression PubMed
Tat tat HIV-1 Tat upregulates the expression of interferon induced transmembrane protein 1 (IFITM1) in human primary T cells PubMed
Vif vif IFITM1 significantly downregulates the expression of HIV-1 Vif by interfering with both Rev/RRE- and Tat/TAR-mediated expression PubMed
Vpr vpr HIV-1 gp160 interacts with IFITM1 PubMed
vpr HIV-1 Vpr upregulates the expression of IFITM1 in human monocyte-derived dendritic cells PubMed
vpr IFITM1, 2 or 3 marginally inhibit the entry of HIV-1 NL4-3 and SIV Mac into TZM-bl by measuring the cleavage of CCF2 by BlaM-Vpr that enters the cytoplasm together with viral cores PubMed
Vpu vpu Vpu34 (a stop-codon at position 35) and EnvG367E mutations rescue HIV-1 replication in IFITM1-expressing SupT1 cells by enhancing HIV-1 cell-to-cell transmission PubMed
capsid gag IFITM1, IFITM2, and IFITM3 proteins (IFITMs) co-localize with HIV-1 CA in velocity gradients, indicating that IFITMs are virion-associated proteins PubMed
gag Endogenous IFITM1/2/3 proteins are upregulated in activated CD4+ T cells and incorporated into HIV-1 Gag/p24-associated virions during infection PubMed
gag Depletion of IFITM1 expression upregulates HIV-1 CA A92E mutant infectivity in CsA-untreated HeLa cells and downregulates its infectivity in CsA-treated HeLa cells PubMed
gag IFITM1 significantly downregulates the expression of HIV-1 Gag and CA by interfering with both Rev/RRE- and Tat/TAR-mediated expression PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ossification IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to interferon-alpha IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to interferon-alpha IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to interferon-beta IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to type II interferon IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
interferon-induced transmembrane protein 1
Names
dispanin subfamily A member 2a
interferon-induced protein 17
interferon-inducible protein 9-27
leu-13 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003641.5 → NP_003632.4  interferon-induced transmembrane protein 1

    Status: REVIEWED

    Source sequence(s)
    AC136475
    Consensus CDS
    CCDS41584.1
    UniProtKB/Swiss-Prot
    P13164, Q15322, Q53XZ0
    UniProtKB/TrEMBL
    A0A7P0T8E0
    Related
    ENSP00000386187.3, ENST00000408968.4
    Conserved Domains (1) summary
    pfam04505
    Location:34 → 98
    CD225; Interferon-induced transmembrane protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    314040..315272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    355743..359591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370307.1 → XP_054226282.1  interferon-induced transmembrane protein 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13164.3 GenPept UniProtKB/Swiss-Prot:P13164

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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