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HNT2 bis(5'-adenosyl)-triphosphatase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851899, updated on 28-Oct-2024

Summary

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Official Symbol
HNT2
Official Full Name
bis(5'-adenosyl)-triphosphatase
Primary source
SGD:S000002713
Locus tag
YDR305C
See related
AllianceGenome:SGD:S000002713; FungiDB:YDR305C; VEuPathDB:YDR305C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
APH1
Summary
Enables ribonucleoside triphosphate phosphatase activity. Involved in nucleoside catabolic process. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in carcinoma (multiple); invasive ductal carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human FHIT (fragile histidine triad diadenosine triphosphatase). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See HNT2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
2
Sequence:
Chromosome: IV; NC_001136.10 (1072746..1073488, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Rsc3p Neighboring gene peptidylprolyl isomerase family protein CPR5 Neighboring gene Pfu1p Neighboring gene tRNA-Val

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of a dinucleoside triphosphatase from Saccharomyces cerevisiae. Brevet A, et al. J Bacteriol, 1991 Sep. PMID 1653209, Free PMC Article
  2. Control of 5',5'-dinucleoside triphosphate catabolism by APH1, a Saccharomyces cerevisiae analog of human FHIT. Chen J, et al. J Bacteriol, 1998 May. PMID 9573184, Free PMC Article
  3. Control of dinucleoside polyphosphates by the FHIT-homologous HNT2 gene, adenine biosynthesis and heat shock in Saccharomyces cerevisiae. Rubio-Texeira M, et al. BMC Mol Biol, 2002 May 20. PMID 12028594, Free PMC Article
  4. Elimination of cap structures generated by mRNA decay involves the new scavenger mRNA decapping enzyme Aph1/FHIT together with DcpS. Taverniti V, et al. Nucleic Acids Res, 2015 Jan. PMID 25432955, Free PMC Article
  5. The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Ahel I, et al. Nature, 2006 Oct 12. PMID 16964241

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables bis(5'-adenosyl)-triphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside triphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleoside catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bis(5'-adenosyl)-triphosphatase
NP_010591.1
  • Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1072746..1073488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180613.1 → NP_010591.1  TPA: bis(5'-adenosyl)-triphosphatase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010591.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G2WB43
    Conserved Domains (1) summary
    cd01275
    Location:16 → 135
    FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...
Nucleotide Protein
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