MHR1 mitochondrial 54S ribosomal protein MHR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MHR1
Official Full Name: mitochondrial 54S ribosomal protein MHR1
Primary source: SGD:S000002704
Locus tag: YDR296W
See related: AllianceGenome:SGD:S000002704; FungiDB:YDR296W; VEuPathDB:YDR296W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: mL67; XTC1
Summary: Enables DNA strand exchange activity and single-stranded DNA binding activity. A structural constituent of ribosome. Involved in several processes, including cellular response to oxidative stress; mitochondrial genome maintenance; and regulation of nucleobase-containing compound metabolic process. Located in mitochondrion and nucleus. Part of mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See MHR1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1055212..1055892)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors show that Mhr1, a protein known to possess homologous DNA pairing activity in vitro, binds to mtDNA double-strand breaks in vivo, indicating its involvement in mtDNA double-strand break repair.
Title: Saccharomyces cerevisiae Mhr1 can bind Xho I-induced mitochondrial DNA double-strand breaks in vivo.
The results suggest that after homologous pairing, the relative activity levels of Din7 and Mhr1 modulate the preference for replication versus homologous recombination to repair double-strand-breaks at ori5.
Title: Din7 and Mhr1 expression levels regulate double-strand-break-induced replication and recombination of mtDNA at ori5 in yeast.
Data indicatete that increases the mtDNA copy number in a manner dependent on Mhr1.
Title: Mitochondrial fusion increases the mitochondrial DNA copy number in budding yeast.
analysis of mutant Mhr1 proteins revealed that Asp69 is involved in Mg(2+)-dependent DNA binding, and that multiple Lys and Arg residues located around Trp71 and Trp165 are involved in the DNA-binding activity of Mhr1
Title: Analysis of DNA-binding sites on Mhr1, a yeast mitochondrial ATP-independent homologous pairing protein.
The putative recombination genes CCE1, DIN7, and MHR1 have overlapping function with the mismatch repair homolog MSH1 in point mutation avoidance and suppression of aberrant recombination events.
Title: Overlapping contributions of Msh1p and putative recombination proteins Cce1p, Din7p, and Mhr1p in large-scale recombination and genome sorting events in the mitochondrial genome of Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA strand exchange activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA strand exchange activity	IEA Inferred from Electronic Annotation more info
enables DNA strand exchange activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial genome maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial genome maintenance	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial genome maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of mitochondrial DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of mitochondrial large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitochondrial 54S ribosomal protein MHR1

NP_010582.3

Mitochondrial ribosomal protein of the large subunit; also involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1055212..1055892

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180604.3 → NP_010582.3 TPA: mitochondrial 54S ribosomal protein MHR1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010582.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSS5, Q06630

UniProtKB/TrEMBL

A6ZYP4, B3LFZ9, C7GQU6, G2WB34, N1PAH2

Conserved Domains (1) summary

pfam12829
Location:24 → 106

Mhr1; Transcriptional regulation of mitochondrial recombination