INM2 inositol monophosphate 1-phosphatase INM2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: INM2
Gene description: inositol monophosphate 1-phosphatase INM2
Primary source: FungiDB:YDR287W
Locus tag: YDR287W
See related: SGD:S000002695; AllianceGenome:SGD:S000002695; VEuPathDB:YDR287W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables inositol monophosphate 1-phosphatase activity. Involved in inositol phosphate dephosphorylation. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability; bipolar disorder; intellectual disability; and schizophrenia. Orthologous to several human genes including IMPA2 (inositol monophosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See INM2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1035995..1036873)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables inositol monophosphate 1-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol monophosphate 1-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol monophosphate 1-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol monophosphate 1-phosphatase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables inositol monophosphate 1-phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables inositol monophosphate 1-phosphatase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables inositol monophosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol monophosphate 4-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol monophosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in inositol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in inositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol phosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in inositol phosphate catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in inositol phosphate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: inositol monophosphate 1-phosphatase INM2

NP_010573.3

EC 3.1.3.25

Inositol monophosphatase; involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1035995..1036873

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180595.3 → NP_010573.3 TPA: inositol monophosphate 1-phosphatase INM2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010573.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSR7, Q05533

UniProtKB/TrEMBL

A0A8H8UNI9, B5VGG3, C7GQT8, C8Z5J9, N1P8J8

Conserved Domains (1) summary

cd01639
Location:13 → 265

IMPase; inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled ...