DPP1 bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: DPP1
Official Full Name: bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase
Primary source: SGD:S000002692
Locus tag: YDR284C
See related: AllianceGenome:SGD:S000002692; FungiDB:YDR284C; VEuPathDB:YDR284C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ZRG1
Summary: Enables diacylglycerol diphosphate phosphatase activity and phosphatidate phosphatase activity. Involved in phospholipid metabolic process. Located in fungal-type vacuole membrane and membrane raft. Orthologous to several human genes including PLPP4 (phospholipid phosphatase 4) and PLPP5 (phospholipid phosphatase 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See DPP1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1030550..1031419, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables diacylglycerol diphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables diacylglycerol diphosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol diphosphate phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lysophosphatidic acid phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidate phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in fungal-type vacuole membrane	HDA more info	PubMed
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase

NP_010570.1

EC 3.1.3.106

EC 3.1.3.4

EC 3.6.1.75

Diacylglycerol pyrophosphate (DGPP) phosphatase; zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1030550..1031419 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180592.1 → NP_010570.1 TPA: bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010570.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSR4, Q05521

UniProtKB/TrEMBL

A6ZYN3, B3LG10, B5VGG2, C7GQT5, C8Z5J6, G2WB23, N1P6S7

Conserved Domains (1) summary

cd03390
Location:50 → 245

PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...