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GTB1 Gtb1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851807, updated on 2-Nov-2024

Summary

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Official Symbol
GTB1
Official Full Name
Gtb1p
Primary source
SGD:S000002629
Locus tag
YDR221W
See related
AllianceGenome:SGD:S000002629; FungiDB:YDR221W; VEuPathDB:YDR221W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to alpha-1,4-glucosidase activity. Involved in N-glycan processing and polysaccharide biosynthetic process. Located in endoplasmic reticulum lumen. Part of glucosidase II complex. Human ortholog(s) of this gene implicated in liver disease and polycystic liver disease 1. Orthologous to human PRKCSH (PRKCSH beta subunit of glucosidase II). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GTB1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (907330..909438)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene septin SPR28 Neighboring gene Mfb1p Neighboring gene uncharacterized protein Neighboring gene Crf1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel role for Gtb1p in glucose trimming of N-linked glycans. Quinn RP, et al. Glycobiology, 2009 Dec. PMID 19542522, Free PMC Article
  2. Yeast GTB1 encodes a subunit of glucosidase II required for glycoprotein processing in the endoplasmic reticulum. Wilkinson BM, et al. J Biol Chem, 2006 Mar 10. PMID 16373354
  3. Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation. Chiolo I, et al. Mol Cell Biol, 2005 Jul. PMID 15964827, Free PMC Article
  4. Identifying Interaction Partners of Yeast Protein Disulfide Isomerases Using a Small Thiol-Reactive Cross-Linker: Implications for Secretory Pathway Proteostasis. Freije BJ, et al. Chem Res Toxicol, 2022 Feb 21. PMID 35084835, Free PMC Article
  5. Systematic bioinformatics and experimental validation of yeast complexes reduces the rate of attrition during structural investigations. Brooks MA, et al. Structure, 2010 Sep 8. PMID 20826334

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Both the MRH and G2B domains of Gtb1p contribute to the Glc2 trimming event but that the MRH domain is essential for Glc1 trimming.
    Title: A novel role for Gtb1p in glucose trimming of N-linked glycans.
  2. GTB1 is required for normal glycoprotein biogenesis; Gtb1p is essential for cleavage of the final glucose.
    Title: Yeast GTB1 encodes a subunit of glucosidase II required for glycoprotein processing in the endoplasmic reticulum.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to alpha-1,4-glucosidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-glycan processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polysaccharide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
 PubMed 
part_of glucosidase II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glucosidase II complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
Gtb1p
NP_010507.3
  • Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    907330..909438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180529.3 → NP_010507.3  TPA: Gtb1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010507.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSK3, Q04924
    UniProtKB/TrEMBL
    A6ZYH5, B3LG66, B5VGA9, C7GVD0, N1P6V5
    Conserved Domains (3) summary
    PRK05771
    Location:127 → 300
    PRK05771; V-type ATP synthase subunit I; Validated
    pfam12999
    Location:28 → 187
    PRKCSH-like; Glucosidase II beta subunit-like
    cl06793
    Location:635 → 695
    PRKCSH; Glucosidase II beta subunit-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04924.1

Gene LinkOut

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