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GIR2 Gir2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851730, updated on 2-Nov-2024

Summary

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Official Symbol
GIR2
Official Full Name
Gir2p
Primary source
SGD:S000002559
Locus tag
YDR152W
See related
AllianceGenome:SGD:S000002559; FungiDB:YDR152W; VEuPathDB:YDR152W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in cytoplasmic translation and positive regulation of cellular response to amino acid starvation. Located in cytoplasm. Orthologous to human RWDD1 (RWD domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GIR2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (765706..766503)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Num1p Neighboring gene putative mRNA-binding protein CTH1 Neighboring gene Ent5p Neighboring gene peptidylprolyl isomerase CPR1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biophysical characterization of Gir2, a highly acidic protein of Saccharomyces cerevisiae with anomalous electrophoretic behavior. Alves VS, et al. Biochem Biophys Res Commun, 2004 Jan 30. PMID 14715270
  2. Gir2 is an intrinsically unstructured protein that is present in Saccharomyces cerevisiae as a group of heterogeneously electrophoretic migrating forms. Alves VS, et al. Biochem Biophys Res Commun, 2005 Jul 1. PMID 15896712
  3. Proteomic analysis reveals complex metabolic regulation in Saccharomyces cerevisiae cells against multiple inhibitors stress. Lv YJ, et al. Appl Microbiol Biotechnol, 2014 Mar. PMID 24442506
  4. Cell growth control by stable Rbg2/Gir2 complex formation under amino acid starvation. Ishikawa K, et al. Genes Cells, 2013 Oct. PMID 23899355
  5. Saccharomyces cerevisiae Rbg1 protein and its binding partner Gir2 interact on Polyribosomes with Gcn1. Wout PK, et al. Eukaryot Cell, 2009 Jul. PMID 19448108, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that Rbg2/Gir2 complex is a modulator that maintains cellular homoeostasis, thus promoting the survival of eukaryotic organisms in stressful environments.
    Title: Cell growth control by stable Rbg2/Gir2 complex formation under amino acid starvation.
  2. Additionally, we describe that the endogenous yeast Gir2 shows heterogeneous electrophoretic mobility, which is not due to proteolytic cleavage.
    Title: Gir2 is an intrinsically unstructured protein that is present in Saccharomyces cerevisiae as a group of heterogeneously electrophoretic migrating forms.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cellular response to amino acid starvation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cellular response to amino acid starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 

General protein information

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Preferred Names
Gir2p
NP_010436.3
  • Highly-acidic RWD domain-containing cytoplasmic protein; forms a highly conserved complex with Rbg2p that is responsible for efficient cell growth under amino acid starvation and binds translational activator Gcn1p in dose-dependent manner according to stress level; associates with translating ribosomes; intrinsically unstructured protein whose stability is enhanced upon binding Rbg2p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    765706..766503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180459.3 → NP_010436.3  TPA: Gir2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010436.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSD4, Q03768
    UniProtKB/TrEMBL
    A6ZYB2, B3LGD0, B5VG47, C7GX34, C8Z567, G2WAQ2, N1P6P3
    Conserved Domains (1) summary
    pfam05773
    Location:5 → 154
    RWD; RWD domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03768.1

Gene LinkOut

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