U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GIS1 histone demethylase GIS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851670, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
GIS1
Official Full Name
histone demethylase GIS1
Primary source
SGD:S000002503
Locus tag
YDR096W
See related
AllianceGenome:SGD:S000002503; FungiDB:YDR096W; VEuPathDB:YDR096W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone H3K36 demethylase activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and regulation of phospholipid biosynthetic process. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in several diseases, including autistic disorder; gastrointestinal system cancer (multiple); head and neck cancer; malignant peripheral nerve sheath tumor; and withdrawal disorder. Orthologous to several human genes including KDM4A (lysine demethylase 4A); KDM4B (lysine demethylase 4B); and KDM4C (lysine demethylase 4C). [provided by Alliance of Genome Resources, Oct 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GIS1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (637139..639823)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene E2 ubiquitin-conjugating protein UBC13 Neighboring gene aminophospholipid-translocating P4-type ATPase DNF2 Neighboring gene mismatch repair ATPase MSH6 Neighboring gene monothiol glutaredoxin GRX3

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The transcription activity of Gis1 is negatively modulated by proteasome-mediated limited proteolysis. Zhang N, et al. J Biol Chem, 2010 Feb 26. PMID 20022953, Free PMC Article
  2. Heme promotes transcriptional and demethylase activities of Gis1, a member of the histone demethylase JMJD2/KDM4 family. Lal S, et al. Nucleic Acids Res, 2018 Jan 9. PMID 29126261, Free PMC Article
  3. The JmjC domain of Gis1 is dispensable for transcriptional activation. Yu Y, et al. FEMS Yeast Res, 2010 Nov. PMID 20868382, Free PMC Article
  4. JmjN interacts with JmjC to ensure selective proteolysis of Gis1 by the proteasome. Quan Z, et al. Microbiology (Reading), 2011 Sep. PMID 21680636
  5. The role of proteosome-mediated proteolysis in modulating potentially harmful transcription factor activity in Saccharomyces cerevisiae. Bonzanni N, et al. Bioinformatics, 2011 Jul 1. PMID 21685082, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate that histone demethylase GIS1 (Gis1)represents a class of multi-functional heme sensing and signaling proteins.
    Title: Heme promotes transcriptional and demethylase activities of Gis1, a member of the histone demethylase JMJD2/KDM4 family.
  2. In vivo experiments showed that, for the Gis1 transcription factor at least, proteasome-mediated control is crucial for a rapid return to growth after nutrient starvation.
    Title: The role of proteosome-mediated proteolysis in modulating potentially harmful transcription factor activity in Saccharomyces cerevisiae.
  3. The data demonstrate that the JmjC domain is dispensable for transcriptional activation by Gis1 during nutrient stress and sporulation.
    Title: The JmjC domain of Gis1 is dispensable for transcriptional activation.
  4. Gis1 is responsible for upregulation of genes during transition from growth to stationary phase.
    Title: Gis1 is required for transcriptional reprogramming of carbon metabolism and the stress response during transition into stationary phase in yeast.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K36 demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K36 demethylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3K9 demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone modifying activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of phospholipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
histone demethylase GIS1
NP_010381.1
  • Histone demethylase and transcription factor; regulates genes during nutrient limitation; activity modulated by proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminus that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; relocalizes to the cytosol in response to hypoxia; GIS1 has a paralog, RPH1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    637139..639823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180404.1 → NP_010381.1  TPA: histone demethylase GIS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010381.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS81, Q03833
    UniProtKB/TrEMBL
    C7GVP2
    Conserved Domains (5) summary
    smart00545
    Location:11 → 52
    JmjN; Small domain found in the jumonji family of transcription factors
    pfam02373
    Location:191 → 307
    JmjC; JmjC domain, hydroxylase
    sd00017
    Location:830 → 851
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:842 → 868
    zf-H2C2_2; Zinc-finger double domain
    pfam13894
    Location:828 → 851
    zf-C2H2_4; C2H2-type zinc finger
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03833.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous