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TVP23 Tvp23p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851657, updated on 2-Nov-2024

Summary

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Official Symbol
TVP23
Official Full Name
Tvp23p
Primary source
SGD:S000002491
Locus tag
YDR084C
See related
AllianceGenome:SGD:S000002491; FungiDB:YDR084C; VEuPathDB:YDR084C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in vesicle-mediated transport. Located in Golgi membrane. Orthologous to several human genes including TVP23C-CDRT4 (TVP23C-CDRT4 readthrough); TVP23A (trans-golgi network vesicle protein 23 homolog A); and TVP23B (trans-golgi network vesicle protein 23 homolog B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TVP23 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (613405..614004, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Stn1p Neighboring gene 25S rRNA (adenine645-N1)-methyltransferase Neighboring gene Afr1p Neighboring gene translocon subunit SSS1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TVP23 interacts genetically with the yeast SNARE VTI1 and functions in retrograde transport from the early endosome to the late Golgi. Stein IS, et al. Biochem J, 2009 Apr 1. PMID 19076069
  2. Conserved Arabidopsis ECHIDNA protein mediates trans-Golgi-network trafficking and cell elongation. Gendre D, et al. Proc Natl Acad Sci U S A, 2011 May 10. PMID 21512130, Free PMC Article
  3. The phox homology (PX) domain protein interaction network in yeast. Vollert CS, et al. Mol Cell Proteomics, 2004 Nov. PMID 15263065
  4. A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. Wendler F, et al. EMBO J, 2010 Jan 20. PMID 19942856, Free PMC Article
  5. A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p). Millson SH, et al. Eukaryot Cell, 2005 May. PMID 15879519, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results indicate that Tvp23p performs a partially redundant function in retrograde transport from the early endosome to the late Golgi.
    Title: TVP23 interacts genetically with the yeast SNARE VTI1 and functions in retrograde transport from the early endosome to the late Golgi.
  2. Tvp proteins collectively assist in the effective maintenance/function of the late Golgi/endosomal compartments.
    Title: Tvp38, Tvp23, Tvp18 and Tvp15: novel membrane proteins in the Tlg2-containing Golgi/endosome compartments of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tvp23p
NP_010369.3
  • Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    613405..614004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180392.3 → NP_010369.3  TPA: Tvp23p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010369.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZY50, D6VS71, P38962
    UniProtKB/TrEMBL
    B3LGI7, B5VFY0, C8Z502, G2WAI9, N1P696
    Conserved Domains (1) summary
    pfam05832
    Location:15 → 156
    DUF846; Eukaryotic protein of unknown function (DUF846)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38962.1

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