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SES1 serine--tRNA ligase SES1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851587, updated on 2-Nov-2024

Summary

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Official Symbol
SES1
Official Full Name
serine--tRNA ligase SES1
Primary source
SGD:S000002430
Locus tag
YDR023W
See related
AllianceGenome:SGD:S000002430; FungiDB:YDR023W; VEuPathDB:YDR023W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables sequence-specific mRNA binding activity and serine-tRNA ligase activity. Involved in seryl-tRNA aminoacylation. Acts upstream of or within positive regulation of tRNA methylation. Located in cytoplasmic stress granule. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human SARS1 (seryl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SES1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (489508..490896)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Atg31p Neighboring gene tRNA-Val Neighboring gene ribosomal 40S subunit protein S11A Neighboring gene Nsi1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of yeast seryl-tRNA synthetase active site mutants with improved discrimination against substrate analogues. Landeka I, et al. Biochim Biophys Acta, 2000 Jul 14. PMID 11004561
  2. Cloning and characterization of the gene coding for cytoplasmic seryl-tRNA synthetase from Saccharomyces cerevisiae. Weygand-Durasevic I, et al. Nucleic Acids Res, 1987 Mar 11. PMID 3031581, Free PMC Article
  3. Yeast seryl-tRNA synthetase expressed in Escherichia coli recognizes bacterial serine-specific tRNAs in vivo. Weygand-Durasević I, et al. Eur J Biochem, 1993 Jun 15. PMID 7686490
  4. The contacts of yeast tRNA(Ser) with seryl-tRNA synthetase studied by footprinting experiments. Dock-Bregeon AC, et al. Eur J Biochem, 1990 Mar 10. PMID 2180700
  5. The C-terminal extension of yeast seryl-tRNA synthetase affects stability of the enzyme and its substrate affinity. Weygand-Durasević I, et al. J Biol Chem, 1996 Feb 2. PMID 8576207

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity, acting on a tRNA IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of tRNA methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in seryl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in seryl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in seryl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine--tRNA ligase SES1
NP_010306.1
  • Cytosolic seryl-tRNA synthetase; class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate; copurifies with Abp140p in an RNA-dependent manner and stimulates 3-methylcytidine (m3C) modification of residue 32 of the tRNA anticodon loop of tRNA-Ser; interacts with peroxin Pex21p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    489508..490896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180331.1 → NP_010306.1  TPA: serine--tRNA ligase SES1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010306.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS09, P07284
    UniProtKB/TrEMBL
    A6ZXY7, B3LGP1, C7GLX3, C8Z4U3, G2WAD0, N1P628
    Conserved Domains (1) summary
    PLN02678
    Location:1 → 449
    PLN02678; seryl-tRNA synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07284.2

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