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SLC1 1-acylglycerol-3-phosphate O-acyltransferase SLC1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851508, updated on 18-Sep-2024

Summary

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Official Symbol
SLC1
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase SLC1
Primary source
SGD:S000002210
Locus tag
YDL052C
See related
AllianceGenome:SGD:S000002210; FungiDB:YDL052C; VEuPathDB:YDL052C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Involved in glycerophospholipid biosynthetic process. Located in lipid droplet. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 1 and lipodystrophy. Orthologous to human AGPAT1 (1-acylglycerol-3-phosphate O-acyltransferase 1) and AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SLC1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (362672..363583, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Mch1p Neighboring gene Pbp4p Neighboring gene Lhp1p Neighboring gene Knh1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Changes in oil content of transgenic soybeans expressing the yeast SLC1 gene. Rao SS, et al. Lipids, 2009 Oct. PMID 19768478
  2. Modification of seed oil content and acyl composition in the brassicaceae by expression of a yeast sn-2 acyltransferase gene. Zou J, et al. Plant Cell, 1997 Jun. PMID 9212466, Free PMC Article
  3. Possible Role of Different Yeast and Plant Lysophospholipid:Acyl-CoA Acyltransferases (LPLATs) in Acyl Remodelling of Phospholipids. Jasieniecka-Gazarkiewicz K, et al. Lipids, 2016 Jan. PMID 26643989, Free PMC Article
  4. Characterization of substrate preference for Slc1p and Cst26p in Saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay. Shui G, et al. PLoS One, 2010 Aug 4. PMID 20694142, Free PMC Article
  5. A family of eukaryotic lysophospholipid acyltransferases with broad specificity. Ståhl U, et al. FEBS Lett, 2008 Jan 23. PMID 18154737

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Saccharomyces cerevisiae Delta9-desaturase Ole1 forms a supercomplex with Slc1 and Dga1.
    Title: Saccharomyces cerevisiae Δ9-desaturase Ole1 forms a supercomplex with Slc1 and Dga1.
  2. pology of 1-acyl-sn-glycerol-3-phosphate acyltransferases SLC1 and ALE1 and related membrane-bound O-acyltransferases (MBOATs) of Saccharomyces cerevisiae.
    Title: Topology of 1-acyl-sn-glycerol-3-phosphate acyltransferases SLC1 and ALE1 and related membrane-bound O-acyltransferases (MBOATs) of Saccharomyces cerevisiae.
  3. Transgenic soybean somatic embryos expressing yeast SLC1 gene show an increase in triacylglycerol content.
    Title: Changes in oil content of transgenic soybeans expressing the yeast SLC1 gene.
  4. in concert with Slc1, Lpt1 plays a central role in Phosphatidic acid biosynthesis, which is essential for cell viability.
    Title: LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae.
  5. Lpt1p, a member of the membrane-bound o-acyltransferase gene family, seems to work in conjunction with Slc1 to mediate the incorporation of unsaturated acyl chains into the sn-2 position of phospholipids.
    Title: Identification of a novel lysophospholipid acyltransferase in Saccharomyces cerevisiae.
  6. Slc1p and Slc4p may not only be active as 1-acylglycerol-3-phosphate O-acyltransferases but also be involved in fatty acid exchange at the sn-2-position of mature glycerophospholipids.
    Title: SLC1 and SLC4 encode partially redundant acyl-coenzyme A 1-acylglycerol-3-phosphate O-acyltransferases of budding yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-acylglycerophosphocholine O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerophospholipid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
1-acylglycerol-3-phosphate O-acyltransferase SLC1
NP_010231.1
  • 1-acyl-sn-glycerol-3-phosphate acyltransferase; catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    362672..363583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180111.1 → NP_010231.1  TPA: 1-acylglycerol-3-phosphate O-acyltransferase SLC1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010231.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRU4, E9P8Y5, P33333
    UniProtKB/TrEMBL
    C7GW89, C8Z4L7, G2WCA8, I6Y6X1, N1P7S3
    Conserved Domains (1) summary
    TIGR00530
    Location:60 → 191
    AGP_acyltrn; 1-acyl-sn-glycerol-3-phosphate acyltransferases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33333.1

Gene LinkOut

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