GEM1 ERMES complex Ca(2+)-binding regulatory GTPase GEM1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GEM1
Official Full Name: ERMES complex Ca(2+)-binding regulatory GTPase GEM1
Primary source: SGD:S000000046
Locus tag: YAL048C
See related: AllianceGenome:SGD:S000000046; FungiDB:YAL048C; VEuPathDB:YAL048C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GON1
Summary: Enables GTPase activity and calcium ion binding activity. Involved in several processes, including mitochondrion inheritance; mitochondrion-endoplasmic reticulum membrane tethering; and phospholipid homeostasis. Located in mitochondrial outer membrane. Part of ERMES complex. Is active in mitochondria-associated endoplasmic reticulum membrane contact site. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human RHOT1 (ras homolog family member T1) and RHOT2 (ras homolog family member T2). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See GEM1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_001133.9 (52801..54789, complement)

Chromosome I - NC_001133.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Absence of Gem1 (mammalian Miro/Rhot) mitigates alpha-synuclein toxicity in a yeast model of Parkinson's disease.
Title: Absence of Gem1 (mammalian Miro/Rhot) mitigates alpha-synuclein toxicity in a yeast model of Parkinson's disease.
Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance
Title: Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance.
Gem1p defines a novel mitochondrial morphology pathway which may integrate cell signaling events with mitochondrial dynamics
Title: Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in heme transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion inheritance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrion inheritance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion-endoplasmic reticulum membrane tethering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ERMES complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in mitochondria-associated endoplasmic reticulum membrane contact site	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	HDA more info	PubMed
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ERMES complex Ca(2+)-binding regulatory GTPase GEM1

NP_009351.1

Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001133.9 Reference assembly

Range

52801..54789 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178193.1 → NP_009351.1 TPA: ERMES complex Ca(2+)-binding regulatory GTPase GEM1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009351.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPG8, P39722

UniProtKB/TrEMBL

A7A0B8, B3LUY4, B5VDH2, C7GPI9, C8Z3G3, N1P9S2

Conserved Domains (4) summary

cd01892
Location:445 → 624

Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal

pfam08355
Location:369 → 434

EF_assoc_1; EF hand associated

pfam08356
Location:236 → 329

EF_assoc_2; EF hand associated

cl38936
Location:6 → 186

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases